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Lipids
Enhancement of loading and oral bioavailability of curcumin loaded self-microemulsifying lipid…
The therapeutic applications of curcumin, a phenolic compound extracted from Curcuma species, is limited due to poor bioavailability. To enhance the bioavailability, self-microemulsifying drug delivery systems (SMEDDS) with curcumin were prepared. Ethyl oleate, Tween 80, and Transcutol® P with…
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Calcitriol Tablets with Hybrid Lipid based Solid Dispersions with Enhanced Stability and Content…
Calcitriol, as the biologically active form of vitamin D3, is essential for patients with renal osteopathy. The solubilization, stabilization, and content uniformity are key issues in its formulation development. In our previous study, the incomplete release of calcitriol was solved by using the…
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Thermodynamic Aspects of the Preparation of Amorphous Solid Dispersions of Naringenin with Enhanced…
Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot- Melt Extruder (HME) using the principle of Low-Temperature Solubilization. Before HME, the NRG-POX solid-state interaction was investigated using Flory…
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Engineering oral delivery of hydrophobic bioactives in real-world scenarios
Bioactive compounds, often hydrophobic in nature, tend to degrade during processing outside or inside the body with rapid clearance rates, resulting in poor bioavailability. In this review, we survey recent scientific advances in lipid-based colloidal delivery systems (conventional…
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Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl…
Excessive exposure to solar radiation induces injurious effects on human skin. Our previous study evidenced that protocatechuic acid (P0) and ethyl protocatechuate (P2) act against photodamage and photoaging. The present study aimed to develop solid lipid nanoparticles (SLNs) and nanostructured…
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Multiple-component dual-phase solid lipid nanoparticles with conjugated transferrin for formulating…
Internal aqueous phase was incorporated in solid lipid nanoparticles (SLNs) containing 5 lipid components to form dual-phase SLNs (DPSLNs), which were then conjugated with transferrin (Tf) to transport nerve growth factor (NGF), rosmarinic acid (ROA), curcumin (CURC) and quercetin (QU) for enhanced…
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Experimental design approach for development of novel microemulsion system and immediate release…
The objective of this study was to determine specific combination of pharmaceutical excipients that lead to formulation of efficient nebivolol hydrochloride SMEDDS and its subsequent formulation into IR-SET (Immediate release- Self emulsifying tablet) which will enhance its solubility and…
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Bioavailability enhancement of repaglinide from transdermally applied nanostructured lipid carrier…
Repaglinide (RG) is an effective anti-diabetic drug (BCS class II) with limited oral bioavailability < 55% due to poor solubility and high first-pass hepatic metabolism. The aim of the paper was to formulate repaglinide loaded nanostructured lipid carrier-gel (RG-NLCs-gel) system to improve the…
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Oral Delivery of Teriparatide Using a Nanoemulsion System: Design, in Vitro and in Vivo Evaluation
PURPOSE:
Investigate the possibility of delivering teriparatide orally using nanoemulsion.
METHOD:
Teriparatide was allowed to interact with chitosan in the presence of HPβCD.The formed polyelectrolyte complex (PEC) was characterized by DSC, FTIR, DLS and for entrapment efficiency. PEC was the…
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Triamcinolone Acetonide-Loaded PEGylated Microemulsion for the Posterior Segment of Eye
Present work investigates the possibility of a polyethyleneglycolylated (PEGylated) microemulsion (ME) to deliver drug to the posterior segment of eye. Triamcinolone acetonide (TA), a widely used drug in intraocular diseases, was selected as the model drug. Based on solubility and emulsification…
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