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Lipids
Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate
Sodium alendronate is a nitrogen-containing bisphosphonate, widely used for osteoporosis treatment. However, due to its several oral administration drawbacks, the transdermal route represents an interesting option. The aim of this study was to formulate sodium alendronate in two submicron delivery…
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Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for…
Leishmaniasis are a group of neglected infectious diseases caused by protozoa of the genus Leishmania with distinct presentations. The available leishmaniasis treatment options are either expensive and/or; cause adverse effects and some are ineffective for resistant Leishmania strains. Therefore,…
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Oral delivery of non-viral nucleic acid-based therapeutics – do we have the guts for this?
Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and poor cellular permeation. The delivery of nucleic acids, in particular by the oral route, remains a major hurdle. This review will focus on the barriers to the oral delivery of nucleic acids and the strategies, in…
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Antifungal and Antiparasitic Drug Delivery
Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis lead to serious chronic illness or even death.
There is a…
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Lipid nanocapsules to enhance drug bioavailability to the central nervous system
The central nervous system (CNS), namely the brain, still remains as the hardest area of the human body to achieve adequate concentration levels of most drugs, mainly due to the limiting behavior of its physical and biological defenses. Lipid nanocapsules emerge as a versatile platform to tackle…
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Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate
Purpose
Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA using a supersaturated silica-lipid hybrid (super-SLH)…
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Phospholipid-Based Delivery Systems – Advanced Vaccines in Modern Medicine
Vaccine Adjuvants
The routine use of vaccines is one of the most out- standing accomplishments of modern medicine. The first major milestone was the eradication of smallpox. Nowadays, emerging pathogens like Sars-CoV-2 require innovative vaccination approaches. Besides the prevention of infectious…
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Development and Optimization of Self-nanoemulsifying Drug Delivery System of Ibrutinib
Objective: The present research demonstrates the formulation of novel self-nanoemulsifying drug delivery system (SNEDDS) for potential delivery of ibrutinib by oral route.
Materials and Methods: Ibrutinib SNEDDS formulation optimized using three-factor, three-level Box–Behnken design and the…
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Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected
Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these uniquely simplified systems in terms of…
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Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study
Ellagic acid (EA) is a potent antioxidant substance of natural origin characterized by poor biopharmaceutical properties and low solubility in water that limit its use. The aim of the present study was to develop lipid-based nanoparticle formulations able to encapsulate EA for dermal delivery. The…
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