Lipids

The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects, noncompliance and patient inconvenience. The application of…
Read More...

Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was designed to prepare and optimize PGL loaded solid lipid nanoparticles (SLNs). The formulation was optimized using three factors lipid (Compritol® 888 ATO - A), surfactant…
Read More...

The oral bioavailability of hydrophilic and macromolecular drugs is generally poor owing to their poor membrane permeability. For example, peptide and protein drugs are poorly absorbed because of their low stability and poor membrane permeability in the gastrointestinal tract. Consequently, these…
Read More...

Recent advances in the field of nanotechnology have given a boost to the academic researchers, the pharmaceutical and biomedical industry, allowing its use in drug delivery and medical diagnosis. Nanotechnology allows the formulation of drug delivery carriers in the nanometer range that helps in…
Read More...

Quercetin was encapsulated in lipid nanoparticles (SLN and NLC) to take advantage of its neuroprotective properties in Alzheimer's disease. The nanoparticles were functionalized with transferrin to facilitate the passage across the blood-brain barrier through the transferrin receptors overexpressed…
Read More...

One of the emerging and recent strategies to combat cancer is application of natural bioactive compounds and phytochemicals. Carotenoids including lycopene, β-carotene, astaxanthin, crocin, β-cryptoxanthin, and lutein, are the main group of plant pigments which play important roles in the prevention…
Read More...

Among various formulations for oral use, lipid-based formulation (LBF) has been expected as a promising technology to improve the absorption of poorly water-soluble compounds. In the current study, three types of LBFs were tested for their effects on the extent, rate and variability of oral…
Read More...

Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This…
Read More...

Background Metastasis causes the most breast cancer-related deaths in women. Here, we investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the treatment of metastatic breast tumors using 4T1-bearing BALB/c mice. Results Solid lipid nanoparticles (SLNs) were…
Read More...

At this years Drug Delivery & Formulation Summit in Berlin, Sharareh Salar-Behzadi hold a presentation and showed this interesting research about Lipid-Based Excipients with Advanced Functionality. Main Topics of the Presentation: Lipid-based Excipient Pharmaceutical Excipients Ideal…
Read More...