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Lipids
Antisolvent precipitation of lipid nanoparticles in microfluidic systems – A comparative study
Microsystems offer promising possibilities to produce nanoparticles which can be used as carriers for poorly water-soluble active substances. The aim of the present study was to compare the preparation of lipid nanoparticles by precipitation in different microsystems: A segmented-flow micromixer, a…
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Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and…
The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®) as carriers for pediatric applications.
The extruded…
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Comparison of two encapsulation processes to protect the commensal gut probiotic bacterium…
Anaerobic commensal gut bacteria are among the most promising future treatments for many diseases. Because of their sensitivity to oxygen and to the harsh conditions of the gut, few studies on formulations that deliver bacteria in a viable and functional form to the intestine have been done.
The…
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Evaluation Of Self-Emulsifying Drug Delivery Systems For Oral Insulin Delivery Using An In Vitro…
The gentle preparation and the functionalization potential of self-emulsifying drug delivery systems (SEDDS) make them an interesting formulation strategy for oral administration of peptide and protein (p/p) drugs.
A series of Kolliphor® RH40 (RH40) and Labrasol® (LAB) glycerides-based SEDDS…
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Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality…
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However, tableting properties of HMC granules have not been studied yet. In…
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Novel approach for overcoming the stability challenges of lipid-based excipients. Part 2:…
The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously introduced polyglycerol esters of fatty acids (PGFAs) with…
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Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening…
The major challenge of conventional lipid-based excipients (LBE) for drug delivery is their unstable solid state, affecting the stability of pharmaceutical product.
Polyglycerol esters of fatty acids (PGFAs) are oligomeric hydroxyethers of glycerol fully or partially esterified with fatty acids.…
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Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid…
The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a quality-by-design (QbD) approach. The BCS class II drug IBU was selected as the model drug for the preparation of…
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Download guidelines and get practical tips for successful formulation of sustained release tablets…
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent:
Drug release from a Compritol® 888 ATO matrix is diffusion controlled and not driven by swelling and erosion. This facilitates simple product design, including straightforward modulation of drug…
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Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to…
Since psoriasis is an immuno-mediated skin disease, long-term therapies are necessary for its treatment. In clinical investigations, tacrolimus (TAC), a macrolide immunosuppressive inhibitor of calcineurin, arises as an alternative for the treatment of psoriasis, acting in some cytokines involved in…
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