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Lipids
Recent strategies and advances in the fabrication of nano lipid carriers and their application…
In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc. Owing to the flexibility and biocompatibility, the lipid-based nanocarriers, including…
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Development of sustained release tablets with Compritol® 888 ATO – guidelines and practical…
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent. These will be explained and illustrated throughout this Guideline.
Download Gattefossé guidelines and get practical tips for successful formulation of sustain release tablets with Compritol® 888 ATO -…
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Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved…
Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low solubility and intestinal glucuronidation. The nano-lipid carriers are characterized by small particle size, biocompatibility, and sustainable properties that improve…
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Design, Optimization and Characterization of Nanostructured Lipid Carriers of Raloxifene…
Raloxifene Hydrochloride (RXL), a BCS class II drug, is used for the treatment of invasive breast cancer and osteoporosis in post menopausal women. Even though the drug is highly efficient, it shows poor bioavailability of 2% when administered orally. The aim of the study was to develop,…
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Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect…
The objective of the study was to assess the effect of enhanced mucoadhesion of a cationic mucoadhesive nanostructured lipid carrier (NLC) on its ocular disposition after topical administration. The NLC was made mucoadhesive by surface coating with chitosan oligosaccharide (COS), a low molecular…
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Fabrication of efavirenz loaded nano-formulation using quality by design (QbD) based approach:…
Quality by design (QbD) approach was practically applied in fabrication of nanostructured lipid carrier (NLC) encapsulating efavirenz (EF) to ensure the quality in product. Initially, risk factors were categorised based on risk priority number (RPN) using risk identification and assessment tools.…
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Semisolid-filled Capsules of Carvedilol for Improving Dissolution Behaviour
The present investigation was aimed at enhancing the dissolution properties of carvedilol, a poorly water-soluble drug using a combination of solid dispersion and semisolid-filled capsule. The use of lauroyl polyoxyl-6 glycerides as a carrier in a semisolid base to improve the dissolution behaviour…
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Novel Approach for Overcoming the Stability Challenges of Lipid-Based Excipients. Part 2:…
The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously introduced polyglycerol esters of fatty acids (PGFAs) with…
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Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly…
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Multifunctional Nanocarriers for Lung Drug Delivery
Nanocarriers have been increasingly proposed for lung drug delivery applications.
The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the…
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