Browsing Category
Lipids
Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
This review is an extensive evaluation and essential analysis of the design and formation of hydrogels (HGs) for drug delivery.
We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis routes, different types, etc.) that influence their…
Read More...
Read More...
Formulation of Ketoconazole Nanocrystal-Based Cryopellets
Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product that rapidly releases the nanocrystals once rehydrated and can be easily processed into a final dosage form (e.g., filled into hard capsule).
Cryopelletisation…
Read More...
Read More...
Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy
Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis.
Due to its poor water solubility and membrane permeability, AmB is…
Read More...
Read More...
Effect of self-emulsifying phase composition on the characteristics of venlafaxine loaded alginate…
In this work, different formulations of alginate beads containing venlafaxine were prepared by ionotropic gelation. The drug was solubilized in a self-emulsifying phase composed of different percentages of Labrasol or Labrafil and tocopherol polyethylene glycol 1000 succinate (TPGS).
Beads were…
Read More...
Read More...
Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic…
Finding an ideal anesthetic agent for postoperative pain control, with long action and low side effects, is still a challenge.
Local anesthetics have potential for such application if their time of action is improved. This work introduces a new hybrid formulation formed by the association of a…
Read More...
Read More...
Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In…
Hypertension shows circadian blood pressure rhythms (day–night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels.
Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and…
Read More...
Read More...
A review on novel methodologies for drug nanoparticle preparation: Microfluidic approach
The intrinsic limitations of conventional dosages have facilitated the emergence of novel drug delivery methodologies. Drug nanonization and encapsulation in polymeric biomaterials offers a new platform to enhance therapeutic efficiency and patient compliance. The two most basic approaches for drug…
Read More...
Read More...
Lipid Nanoparticles by Gattefossé
Lipid-based nanocarriers are promising tools to deliver APIs, including peptides, as their nanosize are in favour of transepithelial transport.
Solid Lipid Nanoparticles (SLN) are composed of lipids in solid state at room and body temperature, usually long chain triglycerides or partial…
Read More...
Read More...
Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion
Neural stem cells (NSC) are located in restricted areas of the central nervous system where they self-renew or differentiate into neurons, astrocytes or oligodendrocytes.
The stimulation of endogenous NSC differentiation is one of the most promising therapeutic approaches to restore neurological…
Read More...
Read More...
Mechanistic Evaluation of Enhanced Curcumin Delivery through Human Skin In Vitro from Optimised…
Curcumin is a natural product with chemopreventive and other properties that are potentially useful in treating skin diseases, including psoriasis and melanoma.
However, because of the excellent barrier function of the stratum corneum and the relatively high lipophilicity of curcumin (log P 3.6),…
Read More...
Read More...