Lipids

Gentamicin is a potent antibiotic with a nephrotoxicity drawback which limits its use. D-α-tocopherol polyethylene glycol succinate (α-tocopherol) is widely used as a surfactant and have potent antioxidant properties. This study aimed to assess the protective effect of α-tocopherol on…
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The aim of the study was to develop a protocol to encapsulate lipidized-peptides in Nanostructured Lipid Carrier (NLC) by High Pressure Homogenization (HPH) for oral delivery. The impact of composition, pressure and number of cycles on particle size, polydispersity index (PDI), and stability was…
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The aim of this work was to develop proliposomal formulations and corresponding liposomes. The focus was on a formulation suitable for large-scale production of PLs using the coating method. In addition, the spray drying process was investigated as production method. Moreover, one main topic was the…
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See the presentation of Sophie Hughes from Gattefossé at CPhI Worldwide where she talked through a poster presentation on the formulating of cannabinoids with lipid excipients. To find out more about this and Gattefossé´s whole portfolio of solutions come to Hall 10.2 Stand B80 and visit our CPhI…
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Gattefossé Techchats Program Easy taste-masking for pediatric medicines development. New Suppocire® grades for flexibility and high performance. How to simplify topical formulations and get great stability and texture. Straight-forward lipid matrix tablet and mini-tablets for…
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Establishing bioequivalence (BE) of ophthalmic emulsions in the absence of in vivo data is challenging. In these emulsions, drug release is a complex process due to drug distribution among various phases which are difficult to characterize. The objective of this study is to investigate the…
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Current study evaluated the processability and characteristics of prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension instead of previously studied API/FA solutions to enlarge the application field of prilling. Metformin hydrochloride (MET) and paracetamol (PAR) were…
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White Paper New Maisine® CC This white paper features Maisine® CC, Gattefossé’s tradename for glyceryl monolinoleate (USP-NF), also known as corn oil mono-, di- and triglycerides. This unique pharmaceutical oil has a long and successful history of use in lipid-based formulation (LBF) for oral…
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Cannabidiol (CBD) has become an industry panacea that’s finding its way into everything from daily supplements to herbal therapies. The market is thriving, with one in seven US consumers relying on therapeutic CBD oils. The United States spends more than $803 million a year on cannabidiol products.…
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With an enhanced understanding of the medicinal benefits and looming ease of regulations around the globe, there is an expressed need for science based, adequately dosed, and age appropriate cannabinoid medicines. The benefits of medicinal cannabinoids include: ✓ Controlled and measured…
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