Lipids

Maisine® CC is a pharmaceutical oily vehicle used to enhance the solubility and oral bioavailability of lipophilic drugs. Maisine® CC is derived from corn oil with a unique and highly reproducible composition in linoleic mono-di and triglycerides. This composition delivers a higher capacity to…
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Meet Gattefossé's experts at AAPS PharmSci 360 November 3-6, 2019 - San Antonio, TX - Congress at booth #1826 and during poster sessions: In vitro evaluation of leuprolide-containing solid lipid-based nanosuspensions: ability to encapsulate, release, protect and permeate in the gastrointestinal…
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HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis. Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), in silico and in vitro studies were performed to…
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Gattefossé published a new Tech` Chats video on Lipid-based formulations in soft gelatin capsules. Following questions are answered beside others in the 7 min video: Why using soft gelatin capsules for lipid-based formulations? How does the capsule machine look like and what to keep in…
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Curcumin, a multi-targeting pharmacologically active compound, is a promising molecule for the treatment of skin inflammation and infection in chronic wounds. However, its hydrophobic nature remains to be a challenge in development of its pharmaceutical products, including dermatopharmaceuticals.…
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Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis. However, the costly status of liposome technology, particularly due to the use of special manufacture equipment and…
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Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra- and intracellular barriers, requiring its…
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Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers…
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It is widely recognised that patient adherence to topical drugs is low because of the complexity or inconvenience of the treatment regimen1 (difficult self- application, number of applications, time consumption, etc.). This leads to poor treatment efficacy in relation to cost.  Adherence has also…
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Conventional quantitation of drug content in the liposome formulation involves the breakdown of bulk liposomes, which ignores details on the distribution of the active pharmaceutical ingredient (API) and excipients in liposomes of different sizes. The objective of this study is to develop an…
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