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Lipids
Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers
Because of excellent bioavailability and high biocompatibility, solid lipid nanoparticles (SLNs) have gained attention in recent years, especially in drug delivery systems.
SLNs are composed of a drug that is loaded in a lipid matrix and stabilized by surfactants. In this work, we have…
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Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant…
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
To this purpose, solid lipid microparticles (SLMs) with Dynasan 114 and a mixture of Dynasan 114 and Dynasan 118…
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Optimization and characterization of rivastigmine nanolipid carrier loaded transdermal patches for…
The present study aimed to develop nanolipid carrier (NLC) loaded transdermal system of rivastigmine for bioavailability enhancement. NLC was optimized using Box-Behnken Design (BBD). Optimized formulation comprises oil (4% w/w), tween 80 (3% w/w) and span 80 (1.8% w/w) and was characterized.
It…
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Excipient-excipient interactions in the development of nanocarriers
Excipient interaction has become essential knowledge for rational formulation design of nanoparticles.
Nanostructured lipid carriers (NLCs) include at least three types of excipient, which enhance excipient
interaction possibilities and relevance.
The present article introduces an alternative…
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Lipid Excipients for Cannabinoid Drug Products
The introduction of the cannabis plant into Western medicine dates to the 19th century when the plant was first used as an additive to patented medicines. The development of cannabis based therapies in the modern sense however came to a halt in the 1970’s after the passing of laws that have since…
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Chemoenzymatic surface modification of liposomal drug carriers
Thesis by Steffen Wöll - Christian-Albrechts-Universität Kiel
Drug encapsulation into a carrier system aims to refine drug characteristics via three major pathways. Firstly, physico-chemical properties may be improved. This includes improvement of solubility or the prevention of drug degradation…
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In-vitro evaluation of solid lipid nanoparticles
Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
Peptides are rarely orally administrated due to rapid degradation in the gastrointestinal tract and low absorption at the epithelial border.
The objective of this study was to encapsulate…
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Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms
Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to meet the demands of modern drugs, their more challenging…
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3D printed lipid based formulations: a step forward!
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
PURPOSE: The use of three-dimensional printing (3DP) in the development of…
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Shedding light on interaction of so called inactive ingredients (excipients) with…
Permeability glycoprotein (P-gp) is a 170 kDa membrane transporter from the category of efflux pumps, which is situated at the apical site of epithelial membrane. P-gp is known to efflux diverse classes of chemical compounds including anticancer agents, antibiotics, steroidal compounds and many…
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