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Lipids
Correlation between the solid state of lipid coating and release profile of API from hot melt coated…
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions.
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Self-emulsifying Drug Delivery Systems and their Marketed Products: A Review
Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs.
SEDDS are isotropic mixtures, consisting of oils, surfactants, and sometimes cosolvents. Designed formulations are used to improve the oral absorption…
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From lead to investigational new drug
The new e-Guide covers successful preclinical studies with Gattefossé excipients. Gattefossé developed a guideline to help formulate molecules with poor solubility and oral bioavailability into more drug-like compounds. The approaches described will provide effective strategies to obtain the target…
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Long-term storage of PEGylated liposomal oxaliplatin
Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer with a favorable toxicity profile.
To move this formulation…
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Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique
Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs.
The objective of the present study was to develop a…
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An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for…
Purpose
Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to develop complex dosage forms of different sizes…
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Drug delivery innovation: Vitamin E TPGS and Polyamino acids
Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as:
solubilizer of poorly soluble drugs
absorption enhancer
emulsifier
vehicle for lipid-based drug…
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Solid lipid particle-based tablets for buccal delivery
This study aims to develop mucoadhesive tablets containing solid lipid particles for controlled release pattern through buccal delivery. The buccal tablets containing drug-loaded solid lipid particles (SLPs) were fabricated using the ultrasonication method and lyophilisation with the incorporation…
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Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for…
The aims of this study were to prepare hydrogenated soybean phosphatidylcholine (HSPC) matrices by hot melt extrusion and to evaluate resulting matrix potential to extend drug release in regard to drug loading and solubility for oral drug delivery of water-soluble drugs.
The liquid crystalline…
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Enhancing dissolution of artesunate from immediate release tablets using a green granulation…
Artesunate is a poorly soluble drug and liable to aqueous hydrolysis. This study aims to formulate Artesunate as an immediate release tablet through optimization of the melt granulation technique to improve the dissolution of the drug. Three different meltable binders were used (Polyethylene Glycol…
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