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Lipids
Lyophilized liposome-based parenteral drug development
Given the successful entry of several liposomal drug products into market, and some with decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to overcome certain limitations of traditional drug delivery, especially for toxic and biologic drugs. This experience has…
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Effects of Drugs and Excipients on Hydration Status
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal…
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Mucus penetrating properties of soft, distensible lipid nanocapsules
Designing nanomaterials to release their drug pay-load upon exposure to an exogenous trigger can help to direct drug delivery, but how the triggered release, which often modifies the nanomaterial properties, influences the biological fate of these systems is currently unknown. The aim of this study…
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Dual Sustained Release Matrix
in this video you discover how dual matrix containing two sustained release(SR) agents, Compritol® 888 ATO and HPMC enables the production of robust SR tablets.
With dual matrix, you can:
reduce the SR agent concentration
reduce the alcohol quantity used in wet granulation process…
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SEDDS for intestinal absorption of insulin
To face the challenges of oral delivery of peptide and protein drugs (P/P drugs), self-emulsifying drug delivery systems (SEDDSs) containing monoacyl phosphatidylcholine (MAPC), Labrasol (LAB) and medium-chain (MC) monoglycerides as permeation enhancers (PEs) were evaluated for their effect on…
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Case Studies on Lipid Excipients
If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration.
How to obtain sustained release tablets of metformin hydrochloride by direct compression?
The aim was to develop dual SR…
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Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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Bioavailability enhancement of poorly soluble drugs: The holy grail in pharma industry
Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe the systemic availability of a drug. Bioavailability assessment is imperative in order to…
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Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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Lipid Excipients for Cannabinoid Drug Products
The introduction of the cannabis plant into Western medicine dates to the 19th century when the plant was first used as an additive to patented medicines. The development of cannabis based therapies in the modern sense however came to a halt in the 1970’s after the passing of laws that have since…
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