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Lipids
A new melatonin oral delivery platform based on orodispersible films
An innovative delivery system for melatonin, based on the incorporation of solid lipid microparticles in orodispersible films (ODFs) made of maltodextrin, was designed and developed. Lipid microparticles at two different melatonin concentrations (10 and 20% w/w) were produced by the spray congealing…
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Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active…
An ideal cancer therapy targets the tumor cells selectively without damaging healthy tissues. Even though the tumor-specific markers are limited, these molecules can be used for the delivery of anti-cancer drugs as an active targeting strategy. Since the lymphatic system plays a critical role in the…
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Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly…
Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery systems (SMEDDS) have gained an increased interest in recent times as a means to enhance the oral bioavailability of poorly water-soluble lipophilic drugs. Upon dilution, SMEDDS self-emulsify in an aqueous…
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Bridging the gaps between academic research and industrial product developments of lipid-based…
Lipid-based formulations, including self-emulsifying drug delivery systems (SEDDS), are an interesting formulation technology that enables the clinical use of compounds for which a low aqueous solubility may be a limitation. From an academic perspective, the technology is interesting on several…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-months storage at 40°. Lactose-containing…
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Lipids and polymers in pharmaceutical technology: lifelong companions
In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and…
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Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents,…
There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of lipid-soluble, water-soluble and amphipathic molecules and compounds…
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Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-month storage at 40°. Lactose-containing…
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Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for…
The therapeutic potential of cannabinoids has been truly constrained heretofore due to their strong psychoactive effects and their high lipophilicity. In this context, precisely due to the lack of psychoactive properties, cannabidiol (CBD), the second major component of Cannabis sativa, arises as…
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