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Lipids
The impact of digestion is essential to the understanding of milk as a drug delivery system for…
Milk has previously been considered as a potential lipid-based drug delivery system for poorly water soluble drugs but it has never gained significant attention. This is in part because relying on solubility in lipid-based formulations (in this case milk) does not provide a complete picture of the…
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High shear blending with glyceryl distearate provides individually coated drug particles for…
Lipid coating in a high shear blender without heating and complex spray mechanism was investigated as a simplified approach to hot melt coating in a fluid bed device. Potassium chloride was coated with 20% glyceryl distearate using both processes. Microscopic images revealed that the drug surface…
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Gelucire: A versatile polymer for modified release drug delivery system
Poly ethylene glycol (PEG) ester surfactants are synthesized by reacting polyethylene glycol with fatty acid. The polyethylene glycol comprises the hydrophilic part of the surfactant and the fatty acid is the lipophilic part. By varying the molecular weight of the PEG and the fatty acid,…
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Review – An update on the use of oral phospholipid excipients
The knowledge and experiences obtained with oral phospholipid excipients is increasing continuously. Nevertheless the present number of oral products using these excipients as essential excipient is very limited. This is remarkable to note, since phospholipids play a significant role in…
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Microencapsulated SLN: An innovative strategy for pulmonary protein delivery
Abstract
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low…
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The effect of a lipid composition and a surfactant on the characteristics of the solid lipid…
Abstract
Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their…
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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl…
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Capsugel Advances the First Intrinsically Enteric Capsule Technology
Capsugel is a global leader in delivering high-quality, innovative dosage forms and solutions to its customers in the health care industry. The company’s Hard Capsule business unit offers customers the broadest portfolio of gelatin, vegetarian and other specialized capsule…
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SYLOID® FP SILICAS – Multifunctional Additives for Better Stability of Botanical
Main Formulation Challenges
The natural product market has experienced tremendous growth in recent years. Botanicals and probiotics are growing
more popular today as people seek out natural remedies to health conditions. Probiotics are “live” organisms, from the
formulations perspective key…
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