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Lipids
Exploring LIPID’s for their Potential to Improves bioavailability of lipophilic drugs candidates: A…
Abstract
This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low…
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Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Abstract
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid…
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Low drug load, high retention mometasone furoate cream with Polyglyceryl – 3 oleate as a…
In the present study, an oil-in-water (O/W) cream containing 0.05% mometasone furoate (MF) was prepared for the treatment of atopic dermatitis (AD) using Polyglyceryl-3 oleate (POCC) as a chemical enhancer. The cream formulation was screened by stability and in vitro skin retention studies and…
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Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
D-limonene, derived from citrus essential oils, holds significant therapeutic potential but faces challenges due to its high volatility, especially in pharmaceutical formulations. This study investigates microemulsions as a promising delivery system for volatile compounds, emphasizing their thermal…
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Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally…
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Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of…
Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics of the obtained systems. The selection of an appropriate…
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Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation
Abstract
Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for preparing various liposomes and other lipid nanoparticles…
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Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of…
Osteoarthritis (OA) is a widespread joint condition affecting millions globally, presenting a growing socioeconomic burden thus making the development of more effective therapeutic strategies crucial. This review emphasizes recent advancements in lipid-based drug delivery systems (DDSs) for…
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Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer…
Abstract
Purpose
The objective of the current research work was to fabricate a fosfestrol (FST)-loaded self-nanoemulsifying drug delivery system (SNEDDS) to escalate the oral solubility and bioavailability and thereby the effectiveness of FST against prostate cancer.
Methods
32 full…
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Processed excipients for targeted drug delivery in cancer management: Enhancing efficacy and…
Processed excipients (PEs) function in creating various dosage forms and need no introduction. For instance, recent studies have shown that PEs oleic acid, which is used with the breast cancer medicine Herceptin, functions both as a liquid delivery system for drugs and has the ability to suppress…
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