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Lipids
Design, Development and Evaluation of Novel Nanoemulgel for Topical Drug Delivery System
Abstract
Objective: The present study is aimed to design, development of nanoemulgel and evaluate for topical drug delivery system. Nanoemulgel prove to be promising carrier for intense amount of poorly penetrable drugs to produce their effect topically.
Methods: FTIR-study was performed to…
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Modern Aspects of Suppositories: A Review
ABSTRACT
Suppositories are an underutilized dosage form. Suppositories are such types of dosage forms used to provide medication via the vaginal and rectal routes. Vaginal suppositories are commonly referred to as pessaries. It was
developed from a formulation called Liquid Enema. Enema has a…
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Enhanced in vivo absorption and biodistribution of curcumin loaded into emulsions with high…
The health benefits of curcumin have been demonstrated by clinical studies, but its low bioavailability compromises its functionality. In this regard, emulsions have proven to be effective encapsulation systems for curcumin. Nevertheless, emulsions with a high oil content (50%) may offer some…
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Guar gum as a microbially degradable component for an oral colon delivery system based on a…
Oral colon delivery has widely been pursued exploiting naturally occurring polysaccharides degraded by the resident microbiota. However, their hydrophilicity may hinder the targeting performance. The aim of the present study was to manufacture and evaluate a double-coated delivery system leveraging…
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QbD-driven development of phospholipid-embedded lipidic nanocarriers of raloxifene: extensive in…
Raloxifene (RLX) is popularly indicated in treatment of osteoporosis and prevention of breast cancer. Owing to its poor aqueous solubility, high pre-systemic metabolism, intestinal glucuronidation, and P-glycoprotein (P-gp) efflux, however, it demonstrates low (< 2%) and inconsistent oral…
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Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment
This review evaluates the literature on nanoparticle-based drug delivery systems for cancer treatment and assesses their efficacy. Nanoparticles have shown potential for improving anticancer agent delivery, reducing systemic toxicity, and enhancing therapeutic outcomes. Extensive studies have shown…
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Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and…
Monoclonal antibodies (mAbs) hold promise for treating Parkinson's disease (PD), but their therapeutic use is hindered by poor delivery to the brain. In this study, we demonstrate that brain-targeted liposomes (BTL) enhance the delivery of mAbs across the blood-brain-barrier (BBB) and into neurons,…
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Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical…
Abstract
Introduction
Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming components by lubricant particles, resulting in decreased…
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Development of Osthole-Loaded Microemulsions as a Prospective Ocular Delivery System for the…
Osthole (OST), a natural coumarin compound, has shown a significant inhibitory effect on corneal neovascularization (CNV). But, its effect on treating CNV is restricted by its water insolubility. To overcome this limitation, an OST-loaded microemulsion (OST-ME) was created to improve the drug’s…
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Design and development of donepezil hydrochloride loaded nanostructured lipid carriers for efficient…
Objective
The primary objective of this study was to develop nanostructured lipid carriers of donepezil hydrochloride (DNZ HCl) for effective management of Alzheimer’s disease (AD).
Significance
Intranasal administration of DNZ NLC containing Nigella sativa (NS) oil as a liquid lipid may…
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