Development of Proliposomal and Liposomal Formulations with Poorly Water-soluble Drugs

The aim of this work was to develop proliposomal formulations and corresponding liposomes. The focus was on a formulation suitable for large-scale production of PLs using the coating method. In addition, the spray drying process was investigated as production method. Moreover, one main topic was the development of a proliposomal formulation with good reconstitutability to generate small MLVs and a high EE. Fenofibrate and ibuprofen were selected as model drugs representing poorly soluble compounds according to Biopharmaceutics Classification System (BCS) class II.

The first part of this work presents the theoretical background of liposomes and PLs. Different classes of liposomes, preparation techniques of liposomes and PLs as well as methods applied for the characterization of liposomes are described. The second part of this work deals with the manufacturing of liposomes via round bottom flask method by modifying different formulation parameters in order to investigate the resulting effect on liposomal size, polydispersity index (PDI) and zeta potential (ZP). Furthermore, the liposomal stability should be improved via pH variation. Download the full dissertation here: dissertation_christinaroedel_final_2.pdf