Pharma Excipients
Liquids
An overview of the methods used to increase the dissolution rate of meloxicam for oral…
Abstract
Oral administration of a drug substance has become one of the most important drug delivery routes. In chronic diseases such as rheumatoid arthritis or osteoarthritis, oral forms of drugs are preferred, not only by patients but also by doctors. Meloxicam (MLX) is pharmacologically…
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Novel Patient-Friendly Orodispersible Formulation of Ivermectin is Associated With Enhanced…
Abstract
Ivermectin has been used since the 1980s as an anthelmintic and antiectoparasite agent worldwide. Currently, the only available oral formulation is tablets designed for adult patients. A patient-friendly orodispersible tablet formulation designed for pediatric use (CHILD-IVITAB) has been…
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Advantages of combining polymers and lipids in extrusion processes
This poster was presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
INTRODUCTION
Hot melt extrusion (HME) has become increasingly popular in pharmaceutical manufacturing over the last
decade1. This…
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Methocel™ Cellulose Ethers – A product that can do it all
THE POSSIBILITIES ARE ENDLESS
Pharmaceutical companies are continuously looking for ways to innovate – through new technologies such as controlled release systems and oral films, or through faster and more efficient manufacturing processes. Did you know that just one product can help do all of…
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Implementation of an at-line nanoparticle size analyzer in a continuous nano-manufacturing line…
Presented at the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, 18 - 21 March 2024, Vienna, Austria:
Introduction
A Process Analytical Technology (PAT) strategy for process and product monitoring is important to ensure adequate
product quality. This is…
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Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory…
Abstract
Active pharmaceutical ingredients (APIs) and excipients can be carefully combined in premix-based materials before being added to dosage forms, providing a flexible platform for the improvement of drug bioavailability, stability, and patient compliance. This is a promising and…
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Formulation Development, Characterization, and Evaluation of Bedaquiline Fumarate -Soluplus® -Solid…
Bedaquiline fumarate (BQF) is classified as a BCS class II drug and has poor water solubility and dissolution rate, which ultimately compromises bioavailability. The objective of this study is to improve the biopharmaceutical properties of BQF through a solid dispersion system by using Soluplus®.…
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Application of Liquisolid Pellets Technology for Improving Dissolution of Posaconazole: A DoE Based…
Abstract
Purpose
Posaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent solubility.
Method
The present investigation was aimed to formulate and evaluate liquisolid pellets of PSZ for improving its…
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Topical pickering emulsion versus classical excipients: A study of the residual film on the human…
Abstract
The interest in Pickering emulsions is based on the possibility of replacing classical emulsifiers with solid particles. These emulsions are very attractive in the pharmaceutical field for their stability virtues and as a vehicle to deliver active ingredients. The study aimed to analyze…
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Development of a stability indicating high-performance liquid chromatography method for…
Abstract
This study presents a stability indicating high-performance liquid chromatography HPLC method for the determination of cenobamate (CNB) in presence of its main impurity (CNB H-impurity) and degradation products. The chromatographic separation was carried out on a Thermo BDS Hypersil-C18…
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