Pharma Excipients
Liquids
Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control
Nanoemulsions are considered as the most promising solution to improve the delivery of ophthalmic drugs. The design of ophthalmic nanoemulsions requires an extensive understanding of pharmaceutical as well as technological aspects related to the selection of excipients and formulation processes.…
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Self-dispersing self-assembling systems for controlled oral delivery of gliclazide
Self-microemulsifying systems undergo self-dispersion to form microemulsion with subsequent self-assembly to form liquid crystalline (LC) and/or gel phases. These transitions modulate the release and absorption pattern of loaded drug. Accordingly, the primary objective was to evaluate these phases…
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SIMALINE™ L80 – Liquid emulsifier for Geltrap™ “Gel-in-oil” and traditional W/O emulsion from…
The value proposition for formulation scientists is:
A novel Gel-in-oil dosage form (Geltrap™) based on regulatory-approved excipients
Able to stabilize high quantities of solvents to solubilize & delivers APIs, thanks to Sepineo polymers
A texture optimal for patient compliance…
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Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery…
NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably…
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Tablet disintegration performance: Effect of compression pressure and storage conditions on surface…
The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does not only refer to the break up of the interparticle bonds, but also relates to the liquid absorption and swelling behaviour of the tablet.
This study demonstrates the…
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The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid…
The aim of this work was to identify from a review of current literature the effects of lipids used in the development of Nanostructured Lipid Carriers (NLCs) on the physicochemical properties of the resulting formulation.
The size of the solid lipid, affected by the molecular weight and the…
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3D-printing of solid lipid tablets from emulsion gels
Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation development is…
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Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for…
Background: The aim of this study is to develop a novel in situ gel of tacrolimus-loaded SLNs (solid lipid nanoparticles) for ocular drug delivery.
Methods: The optimal formulation was characterized by surface morphology, particle size, zeta potential, entrapment efficiency, drug loading and in…
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In-Silico Screening of Lipid-Based Drug Delivery Systems
Purpose
This work proposes an in-silico screening method for identifying promising formulation candidates in complex lipid-based drug delivery systems (LBDDS).
Method
The approach is based on a minimum amount of experimental data for API solubilites in single excipients. Intermolecular…
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3D Printing of Core–Shell Capsule Composites for Post‐Reactive and Damage Sensing Applications
3D printing of multicomponent materials as an advantageous method over traditional mold casting methods is demonstrated, developing small core–shell capsule composites fabricated by a two‐step 3D printing process. Using a two‐print‐head system (fused deposition modeling extruder and a liquid inkjet…
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