Pharma Excipients
Liquids
Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing…
In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH media showed a pH-independent solubility. Phase solubility…
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Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based…
One of the main problems with NSAIDs is the dosing frequency, which leads to patients’ noncompliance. To overcome this, fabrication of sustained release formulation of the drug is considered a well-reputed technique. The present study aimed to develop sustained release formulation of a model drug…
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Efficient skin delivery with Transcutol P
Transcutol® P is a high purity grade of diethylene glycol monoethyl ether (DEGEE) manufactured by the condensation of ethylene oxide and ethanol, followed by distillation. The presence of an ether and an alcohol function explains the exceptional solubilizing capacity of this solvent.
A…
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Suitability of phosphatidylcholine-based formulations for liquid filling in hard capsules
The current study aimed to evaluate whether phosphatidylcholine-based formulations have suitable properties for liquid filling in hard capsules. Liquid or semisolid formulations were obtained with Miglyol 812 (medium chain triglycerides) or Softisan 378 (semisolid hard fat), respectively, in…
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The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients
The Chinese medicinal materials originate from animals, plants, or minerals must undergo appropriate treatment before use as decoction pieces. Processing of Chinese medicines with liquid excipients is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces which are…
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European Paediatric Formulation Initiative workshop report: Improving the administration of oral…
Accurate dosing of the right medicine to the right patient is a key element of safe and efficacious pharmacotherapy, yet prone to technical challenges and human error when dosing involves the administration of small volumes of liquid medicines. For this reason, the topic has gained increased…
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Hydroalcoholic Gel – improvement opportunities to increase daily hygiene
Hydroalcoholic Gel: A range of polymers to formulate with high level of ethanol
Daily hygiene helps to limit illness. Hydroalcoholic gels are mainly composed of high level of alcohol for its disinfecting properties. This high amount of alcohol can destabilize the gel decreasing viscosities, give…
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Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid…
The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a quality-by-design (QbD) approach. The BCS class II drug IBU was selected as the model drug for the preparation of…
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Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Despite the increasing interest in pharmaceutical use of mesoporous silica, there is still only limited knowledge on mechanisms of pore loading and subsequent drug desorption and release. Hence the aim of this work was to address the mechanistic aspects of drug loading into the mesoporous silica…
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Benznidazole Self-Emulsifying Delivery System: A Novel Alternative Dosage Form For Chagas Disease…
Benznidazole (BZ) tablets are a unique form of treatment available for treating Chagas disease. Development of a liquid formulation containing BZ easy to administer orally for the treatment of paediatric patients, particularly for newborns is urgently required, with the same efficacy, safety and…
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