Pharma Excipients
Liquids
Effect of Binder Attributes on Granule Growth and Densification
The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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Sugars with different thickening power in high shear granulation
Sugars and sweeteners are common ingredients in foods and also in pharmaceutical industries. They are soluble and sticky ingredients and their processing in granulators may be difficult since they can easily adhere to mixer walls or lead to uncontrolled granule growth. The purpose of this…
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The Development of Self-nanoemulsifying Liquisolid Tablets to Improve the Dissolution of Simvastatin
02. March 2017
Abstract
The aim of this work was to develop self-nanoemulsifying liquisolid tablets (SNELT) to enhance the dissolution profile of poorly water-soluble simvastatin. SNELT present a unique technique of incorporating self-nanoemulsifying drug delivery systems (SNEDDS)…
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Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs
19. January 2017
Abstract
The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules such as peptides. We hypothesized that this mechanism could have utility for poorly soluble small molecules by utilizing a mucoadhesive polymer as the…
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An evaluation of tools via patient-reported outcome measures to assess the acceptability of existing…
16. January 2017
Introduction
Palatability of liquid medicines is a recognised challenge within the paediatric population
Acceptability: “The overall ability of the patient and its caregiver to use the medicine as intended”
Patient needs must be met when medicines are…
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Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central role in delivering the drug in a safe and effective manner.…
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Development and characterization of the voriconazole loaded lipid-based nanoparticles
08. October 2016
Abstract
The number of topical fungal infections is growing, mostly owing to immunosuppressive therapy. Several topical fungal infections, such as eye mycoses, can be treated by local administration of antimycotic drugs. One major group of the antifungal agents is…
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Design and Evaluation of Solubility Enhancement of Poorly Soluble Drugs using Liquid Solid Compacts
30. September 2016
ABSTRACT
Oral dosage form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by the oral route. The poor dissolution rate of water insoluble drugs is still a substantial problem…
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Formulation and evaluation of Deflazacort liquisolid tablets
19. May 2016
In the present investigation, liquisolid compact technique is investigated as a tool for enhancement of dissolution of poorly water-soluble drug, Deflazacort. Deflazacort liquisolid tablets were prepared using propylene glycol as non-volatile liquid vehicle,…
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Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic…
21. October 2015
Nowadays exploration of novel lipid-based formulations is akin to a magnet for researchers worldwide for improving the in vivo performance of highly lipophilic drugs. Over the last few years, new compositions of lipids have been developed, and the probable…
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