Pharma Excipients
Liquids
Premix technologies for drug delivery: manufacturing, applications, and opportunities in regulatory…
Abstract
Active pharmaceutical ingredients (APIs) and excipients can be carefully combined in premix-based materials before being added to dosage forms, providing a flexible platform for the improvement of drug bioavailability, stability, and patient compliance. This is a promising and…
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Formulation Development, Characterization, and Evaluation of Bedaquiline Fumarate -Soluplus® -Solid…
Bedaquiline fumarate (BQF) is classified as a BCS class II drug and has poor water solubility and dissolution rate, which ultimately compromises bioavailability. The objective of this study is to improve the biopharmaceutical properties of BQF through a solid dispersion system by using Soluplus®.…
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Application of Liquisolid Pellets Technology for Improving Dissolution of Posaconazole: A DoE Based…
Abstract
Purpose
Posaconazole (PSZ) is BCS class-II drug that displays variable bioavailability upon oral administration due to extremely low and pH-dependent solubility.
Method
The present investigation was aimed to formulate and evaluate liquisolid pellets of PSZ for improving its…
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Topical pickering emulsion versus classical excipients: A study of the residual film on the human…
Abstract
The interest in Pickering emulsions is based on the possibility of replacing classical emulsifiers with solid particles. These emulsions are very attractive in the pharmaceutical field for their stability virtues and as a vehicle to deliver active ingredients. The study aimed to analyze…
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Development of a stability indicating high-performance liquid chromatography method for…
Abstract
This study presents a stability indicating high-performance liquid chromatography HPLC method for the determination of cenobamate (CNB) in presence of its main impurity (CNB H-impurity) and degradation products. The chromatographic separation was carried out on a Thermo BDS Hypersil-C18…
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Development and application of control concepts for twin-screw wet granulation in the ConsiGma-25:…
Abstract
Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating Quality by Control (QbC) algorithms as a standard component of…
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The most recent advances in liquisolid technology: Perspectives in the pharmaceutical industry
Abstract
Hydrophobic drugs exhibit altered bioavailability and pose other challenges at an industrial level due to their poor solubility and dissolution rates. In addition, poor flowability, compressibility, complex dosing schedules, and light-sensitivity problems associated with hydrophobic…
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Skin-friendly textures – by Gattefossé
Caring for patients
Patient preferences and needs as well as therapeutic indication should be considered at early stage of development of topical or transdermal formulations.
To increase adherence to skin treatments, it is important to consider patient’s needs, when designing the dosage…
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Precision in Every Drop: The Potential of Refined Soybean Oil in Lipophilic Drugs
ADM´s Refined Soybean Oil IV is a highly purified soybean oil fully compliant with the:
"European Pharmacopoeia (1473) and United States Pharmacopeia/National Formulary (USP/ NF) monographs and general notices"
intended for use in the manufacturing of pharmaceutical products.…
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Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming…
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