Pharma Excipients
Liquids
The Past, Present, and Future of Oral Dosage Forms for Children
Abstract
The administration of medications to children has been a challenge for parents and caregivers for generations. Pharmaceutical companies have often overcome the difficulties of weight-based dosing and the inability of most young children to swallow solid dosage forms by creating oral…
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HME as Advanced Approach for Development of Solid Self Emulsifying Drug Delivery System
The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous published publications over the past five years show that hot…
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Simultaneous photo-induced polymerization and surface modification by microfluidic spinning to…
Functionalized polymer fibers were prepared by microfluidic spinning involving simultaneous photopolymerization and surface modification. A capillary-based microfluidic device was used with two miscible coaxially co-flowing phases to afford polymer fibers by the photopolymerization of poly(ethylene…
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Potentially Harmful Excipients: State of the Art for Oral Liquid Forms Used in Neonatology and…
Abstract
The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly for neonates. Toxicity and efficacy divergences have been…
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Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric…
Abstract
Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its development is necessary. Palatability (appreciation of smell,…
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Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in…
Abstract
Drug loading into mesoporous carriers may help to improve the dissolution of poorly aqueous-soluble drugs. However, both preparation method and carrier properties influence loading efficiency and drug release. Accordingly, this study aimed to compare two preparation methods: formulation…
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Dispensing Oral Temozolomide in Children: Precision and Stability of a Novel and Ready to Use Liquid…
Abstract
Temozolomide (TMZ) is part of the therapeutic armamentarium used in managing pediatric cancers; however, available oral forms (capsules) are not adapted for use in children. Our aim was to assess the dose accuracy and stability of TMZ using capsule contents mixed with food compared with a…
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Drying liquids – Selecting the best technology for nutraceuticals
The desired end product properties can make a difference when choosing between spray drying or spray granulation
Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most effective process will often be dictated by the desired properties…
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Combining the potential of 3D printed buccal films and nanostructured lipid carriers for…
Abstract
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges…
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Solid dispersion technology with porous material – Telmisartan
1. Introduction
Solid dispersion is one of the most effective technologies to improve API characteristics such as solubility, stability, and compressibility. Recently developed small molecule APIs with the aim to higher therapeutic effects, tend to become poor soluble, as much as 70% or higher…
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