Pharma Excipients
Liquids
Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of…
In the pharmaceutical industry, the coating of particles is a widely used technique to obtain desired surface modifications of the final product, e.g., controlled release of the active agents. The production of round, coated particles is particularly important, which is why fluidized bed rotor…
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Stability of APIs in Super Refined Oils – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Excipient choice can make all the difference in successful formulation development. The selection of pharmaceutical excipients in a drug formulation can have a significant impact on development timescales, Active Pharmaceutical Ingredient (API)…
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Development of an Oral Liquid Formulation of Nicardipine Hydrochloride Compounded with Simple…
Nicardipine hydrochloride is an anti-hypertensive drug that is used off-label to treat hypertension in children. A previous oral formulation of nicardipine hydrochloride was developed using a commercial vehicle as an excipient. However, ready-to-use vehicles are prone to supply shortages, and their…
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Thermodynamic Mechanism of Physical Stability of Amorphous Pharmaceutical Formulations
Hygroscopicity is an important factor affecting the physical stability of amorphous solid dispersions (ASDs) during long-term storage. In this work, the effects of temperature, relative humidity (RH), and polymeric excipients on the phase behavior of amorphous irbesartan (IRB) and oxaprozin (OXA)…
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PHOSAL® H 50: Liquid Phospholipids Derived from Sunflower
The Natural All-Rounder
Lipoid’s PHOSAL® H 50 is a liquid formulation of purified phosphatidylcholine (PC) and oil from 100 % sunflower. This unique, pure and natural liquid formulation can serve as a solubilizer for lipophilic actives and can help to disperse lipid phases into aqueous systems by…
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Soluplus® promotes efficient transport of meloxicam to the central nervous system via nasal…
In our present series of experiments, we investigated the nasal applicability of the previously developed Soluplus® - Meloxicam polymeric micelle formulation. Utilizing the nasal drug investigations, moderately high mucoadhesion was experienced in nasal conditions which alongside the appropriate…
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Inkjet drug printing onto contact lenses: Deposition optimisation and non-destructive dose…
Inkjet printing has the potential to advance the treatment of eye diseases by printing drugs on demand onto contact lenses for localised delivery and personalised dosing, while near-infrared (NIR) spectroscopy can further be used as a quality control method for quantifying the drug but has yet to be…
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Compatibility Study between Fenbendazole and Polymeric Excipients Used in Pharmaceutical Dosage…
The body of work described in this research paper evaluates the compatibility between Fenbendazole (Fen), which is a broad-spectrum anthelmintic with promising antitumor activity, and three polymeric excipients commonly applied in pharmaceutical dosage forms. The assessment of binary mixtures was…
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A functional study of tubing material for the spray drying of mRNA-lipoplexes
Kiel University, Germany, and Meggle GmbH & Co. KG present "A functional study of tubing material for the spray drying of mRNA-lipoplexes":
INTRODUCTION
The overall aim of this project is the development of an inhalable dry powder platform for mRNA vaccines.
As many viral infections…
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Dissolution and Absorption of Inhaled Drug Particles in the Lungs
Dry powder inhalation therapy has been effective in treating localized lung diseases such asthma, chronic obstructive pulmonary diseases (COPD), cystic fibrosis and lung infections. In vitro characterization of dry powder formulations includes the determination of physicochemical nature and aerosol…
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