Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics of lactose monohydrate (LMH) by co-processing by fluid-bed melt granulation…
Read More...
Read More...
3D-Printed Coating of Extended-Release Matrix Tablets Effective Tool for Prevention of…
Tablets used for extended drug release commonly contain large amounts of drugs. The corresponding drug release mechanism thus has to be well-known and invariable under numerous conditions in order to prevent any uncontrolled drug release. Particularly important is the stability and invariability of…
Read More...
Read More...
New all-in-one tableting solution with filler, binder, disintegrant and lubricant: Kollitab™ DC 87 L
How can Kollitab™ DC 87 L help you?
Superior flowability
High tablet strength at broad compression forces
Fast disintegration
Order Kollitab™ DC 87 L here!
Key benefits
Manufacturing
Enables fast tablet development
Simplifies formulation development
Reduces…
Read More...
Read More...
Effect of binder type and lubrication method on the binder efficacy for direct compression
The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers and combined with ten binders (10, 20 and 30% w/w). Binder properties were linked to tensile strength via…
Read More...
Read More...
Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to…
One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing and release. We have developed a novel dual material…
Read More...
Read More...
Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles
Applying additives and excipients during the dry processing of fine particles is a common measure to control the particle–particle interactions, to specifically influence the powder properties and to enhance the process efficiency or product quality. In this study, the impacts of a particulate…
Read More...
Read More...
Binder-free twin-screw melt granulation: an effective approach to manufacture high-dose API…
This study investigates the use of twin-screw binder-free melt granulation (BFMG) in the development of high-dose solid dose formulations for low melting point thermally stable drugs. Both ibuprofen and guaifenesin are examined. By granulating pure API powder, it is shown that BFMG can successfully…
Read More...
Read More...
Introduction to LUBRI-PREZ – the new Magnesium Stearate
Introduction
Lubricants play a critical role in the development process of tableting and capsule filling. For decades, magnesium stearate has been the most commonly used lubricant in pharmaceutical and nutraceutical tablet formulations, offering both functionality and cost-efficiency.
As a…
Read More...
Read More...
Preparation of Insoluble Matrix Tablets of Theacrine
Background: Theacrine (1,3,7,9-tetramethyluric acid, TC) is a purine alkaloid rich in the tender leaves of an unusual Chinese tea known as Kucha. TC possessed diverse pharmacological activity including antioxidative, anti-inflammatory, analgesic and anti-depressive effects.
Aim In this work,…
Read More...
Read More...
Critical Tools in Tableting Research: Using Compaction Simulator and Quality by Design (QbD) to…
As commonly known, the product development stage is quite complex, requires intensive knowledge, and is time-consuming. The selection of the excipients with the proper functionality and their corresponding levels is critical to drug product performance. The objective of this study was to apply…
Read More...
Read More...