Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the powder. In this work, we studied the influence of the speed on…
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Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low material consumption, and high instrumentation to generate the most possible process understanding. However, their capability of resembling general…
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Defining design space for optimization of escitalopram ultra-fast melting tablet using suspension…
In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast melting tablets (UFMTs) based on QbD approach using suspension…
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Three-dimensional aspects of formulation excipients in drug discovery: A critical assessment on…
Formulation/pharmaceutical excipients play a major role in formulating drug candidates, with the objectives of ease of administration, targeted delivery and complete availability. Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery. These orphan…
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Problems during tablets manufacturing
Learn more about capping, lamination, picking and sticking as well as mottling, weight and hardness variations in tableting. All brought to to by Dr. Karim Maarif - founder of KMCD
Download the presentation here: some_basic_information_about_punches_tabletting_cycle__1581894721.pdf
Dr. Karim…
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Benefits of Co-processed High-Functionality Excipients in a Continuous Direct Compression Process…
Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling experiments. With these benefits, come challenges as well. In a fully continuous process, the excipients must be added through individual…
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Towards a molecular understanding of the impact of crystal size and shape on punch sticking
Punch sticking during tablet manufacturing is a common problem facing the pharmaceutical industry. Using several model compounds, effects of crystal size and shape of active pharmaceutical ingredients (API) on punch sticking propensity were systematically investigated in this work to provide…
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Investigation of powder flowability at low stresses: Influence of particle size and size…
At moderate stresses, shear cells are the preferred method of powder flow measurement. However, several industrial processes operate at low stresses, where the determination of unconfined yield strength by the shear cell technique may be inconsistent, or found not to correlate with observed…
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Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality…
This study aimed to transfer a high shear granulation (HSG) process to a twin-screw granulation (TSG) process while maintaining equivalent dissolution profiles. Ibuprofen (IBP) was used as poorly soluble model drug. Granules were obtained by HSG or TSG according to a full factorial design.
The…
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Monitoring lubricant addition in pharmaceutical tablet manufacturing through passive vibration…
In tablet manufacturing, a lubricant is added in a tumbling mixer prior to compression to ensure that the tablet is ejected smoothly without sticking or breakage. Control and monitoring of this process is critical as process parameters can negatively affect final tablet properties. Inline monitoring…
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