Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
PVA in Sustained Release Matrix Tablets – Wet Granulated vs Direct Compression – Poster
Polymer-based long-acting matrix tablets are often used to ensure patient compli- ance and API efficacy of orally applied drugs. Increasingly, polyvinyl alcohols (PVAs) are used as hydrophilic, swellable and erodible matrices in such sustained release (SR) tablets, as they show a prolonged API…
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A systematic evaluation of poloxamers as tablet lubricants
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution.
In this…
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Roller compaction
Roller compaction is the main technique employed in dry granulation.
Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the…
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Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Impact of Die Wall Material on the Mechanical Properties of Paracetamol Tablets
Tablet quality can be affected by material, configuration and design of the tooling which comprise punches and dies. Much research attention had centred around punches, with very little reported on the dies.
Dies with modified bore lining materials or inserts are available for special…
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On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?
Oral direct compressible tablets are the most frequently used drug products. Manufacturing of tablets requires design and development of formulations, which need a number of excipients. The choice of excipients depends on the concentration, manufacturability, stability, and bioavailability of the…
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Direct Compression of Lactase Tablets with PROSOLV® EASYtab Nutra
The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most suitable tableting process.
The performance of pure lactase…
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Semi-Solid Topical Formulary
Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or oil-in-water emulsions.
BASF offers an unparalleled…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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