Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
A Big Data Approach to Pharmaceutical Flow Properties
Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need to better understand and share the typical flow properties…
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Direct compression tablet containing 99% active ingredient – a tale of spherical crystallization
Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, since it only involves blending and compression. However, active pharmaceutical ingredients (API) generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of…
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Gas adsorption on commercial magnesium stearate: The origin of atypical isotherms and BET transform…
The causes of atypical nitrogen adsorption isotherm features of commercial magnesium stearate grades have been investigated through a combination of alternative adsorbates and variation of analytical conditions. Atypical features have previously been identified as having poor linearity of adsorption…
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Introduction to pharmaceutical excipients – a video
In this video Chris Moreton gives an interesting insight on pharmaceutical excipients.
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Roller compaction: Improving the homogeneity of ribbon properties along the roller width
A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The porosity distribution resulting from the applied stress, was…
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Orally disintegrating dosage forms
What is an orally disintegrating dosage form?
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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A systematic evaluation of dual functionality of sodium lauryl sulfate as a tablet lubricant and…
Appropriate lubrication is important in tablet manufacturing as it lowers punch sticking propensity and protects tooling by reducing friction between die wall and tablet during tablet manufacturing. Most commercial lubricants negatively impact tabletability and dissolution. A delicate balance is…
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Spectroscopic characterization of tablet properties in a continuous powder blending and tableting…
17. July 2018
By the advent of continuous pharmaceutical manufacturing, fast and accurate characterization of product quality has become of a major interest. Although it also promotes the real-time release testing approach, so far mainly content uniformity studies were…
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Excipient Selection Considerations
The selection of the excipients(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be
Dose
Particle Size
Flow Properties
Bulk Density
Moisture…
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Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid…
09. May 2018 The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties. The study consisted of preparingglyceryl behenate SLN…
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