Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
The Utilization of Surface Free Energy for Predicting Flowability of Filler-Lubricant or…
31. January 2017
The aim of this study was to apply the knowledge of surface free energy for the flowability prediction of pharmaceutical excipients. In order to predict the flowability, the spreading coefficient was calculated from the surface free energy of each material using Wu's…
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Gellan Gum Fluid Gels for Topical Administration of Diclofenac
30. October 2016
Abstract
Diclofenac topical formulations are often preferred for drug administration to patients who experience serious GIT problems. Absorption of the drug through the skin, however, can be challenging due to the natural protective feature of the stratum corneum…
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Design and Evaluation of Solubility Enhancement of Poorly Soluble Drugs using Liquid Solid Compacts
30. September 2016
ABSTRACT
Oral dosage form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by the oral route. The poor dissolution rate of water insoluble drugs is still a substantial problem…
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Lubricant-Induced Crystallization of Itraconazole From Tablets Made of Electrospun Amorphous Solid…
14. June 2016
Abstract
Investigation of downstream processing of nanofibrous amorphous solid dispersions to generate tablet formulation is in a quite early phase. Development of high speed electrospinning opened up the possibility to study tableting of electrospun solid…
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Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet…
15. June 2016 Context: The negative impact of magnesium stearate on the hardness of tablets is a well-known phenomenon, but the influence of paddle movement in the forced feeder on the lubricant effect during tablet compression is…
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Lubricants in Pharmaceutical Solid Dosage Forms
Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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Arecor awarded TSB grant to support expanded protein stability platform
Arecor Limited has been awarded a prestigious Technology Strategy Board (TSB) grant to apply its proprietary technology for developing stable formulations of protein drugs.
Many of the next generation of protein drugs are often unstable and difficult to manufacture and maintain…
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