Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Implementation of Quality by Design (QbD) for Development of Bilayer Tablets
Bilayer tablets offer various drug release profiles for individual drugs incorporated in each layer of a bilayer tablet, which is rarely achievable by conventional tablets. These tablets also help avoid physicochemical incompatibilities between drugs and excipients. Successful manufacturing of such…
Read More...
Read More...
Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct…
Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study. Famotidine/mannitol (FA/MA) binary solution was spray dried…
Read More...
Read More...
Engineered Lipid Excellence Quality & Regulatory – IOI Oleo
See the brochure by IOI Oleo Pharma about their Quality & Regulatory:
EXCIPIENTS & ACTIVE PHARMACEUTICAL
INGREDIENTS - MADE IN GERMANY
Founded in 1905, IOI Oleo’s manufacturing site in Witten has been engaged since the beginning of the 1950s in the manufacturing of…
Read More...
Read More...
Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor…
Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product. The method examined small-scale particulate solids in motion…
Read More...
Read More...
Introducing the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of…
See the fifth issue of Fuji Chemical Industries Technical Newsletter. It presents the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of Simvastatin.
ORAL DISINTEGRATING TABLETS OF SIMVASTATIN WITH F-MELT®
F-Melt® is a co-processed spray-dried excipient system…
Read More...
Read More...
Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and Neusilin® US2) through a screening plan. The enhancement of…
Read More...
Read More...
Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet…
As the pharmaceutical industry increasingly adopts the Pharma 4.0. concept, there is a growing need to effectively predict the product quality based on manufacturing or in-process data. Although artificial neural networks (ANNs) have emerged as powerful tools in data-rich environments, their…
Read More...
Read More...
Insights into the Multiscale Lubrication Mechanism of Edible Phase Change Materials
Investigation of a lubrication behavior of phase change materials (PCM) can be challenging in applications involving relative motion, e.g., sport (ice skating), food (chocolates), energy (thermal storage), apparel (textiles with PCM), etc. In oral tribology, a phase change often occurs in a sequence…
Read More...
Read More...
Upscaling of external lubrication from a compaction simulator to a rotary tablet press
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction…
Read More...
Read More...
A Novel Approach of External Lubrication in a Rotary Tablet Press Using Electrostatics
Abstract
Purpose
In powder compaction on rotary tablet presses, the addition of a lubricant is normally mandatory. However, the typical internal lubrication method tends toward overlubrication, resulting in an alteration of the critical quality attributes of the product. In this study, the…
Read More...
Read More...