Lubricant excipients are substances that are added to tablet formulations to aid in the tableting process and to improve the flow of powders during the manufacturing of tablets. These excipients reduce friction and prevent the sticking of the tablet material to the surface of the die and punches, allowing for smoother tablet production and reducing the wear and tear on the tableting equipment.
Pharma Excipients
Lubricant
Screening of lubricants towards their applicability for external lubrication
Internal lubrication is associated with decreasing tensile strength and prolonged disintegration. These effects can be minimized using external lubrication. In current study, six lubricants (magnesium stearate, sodium stearyl fumarate, stearic acid, glyceryl dibehenate, poloxamer 188 and sucrose…
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Microcrystalline cellulose promotes superior direct compressed Boesenbergia rotunda (L.) Mansf.…
This work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf. extract tablet. Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried rice starch, and spray-dried lactose were used. MCC exhibited superior performance to the other diluents by providing the…
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Tablet Disintegratability: Sensitivity of Superdisintegrants to Temperature and Compaction Pressure
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects of temperature and compaction pressure on tablet…
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Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental…
Scanning electron microscopy-based energy dispersive X-ray spectroscopy (SEM-EDS) is proposed as a versatile tool for quantifying surface area coverage (SAC) by magnesium stearate (MgSt) on pharmaceutical tablets and particles. Our approach involved fast elemental mapping and subsequent SAC…
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Clean label ingredients for solid oral dosage forms
In general, clean label is a consumer driven movement, demanding a return to real food and transparency through authenticity. For nutritional supplements, this means that they should contain natural, familiar, simple ingredients that are easy to recognize, understand and pronounce.
Therefore, the…
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LUBRITAB RBW – The Clean Label Lubricant for Tablet and Capsule Formulations
LUBRITAB® RBW (Rice Bran Wax) is the innovative all-natural lubricant designed to meet growing clean label demands. Derived from rice, this plant-based ingredient is gluten-free, and offers a sustainable solution for tablet and capsule formulations.
Benefits
• The only clean…
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AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and parenteral drug products can reduce your project risk,…
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Preparation and Evaluation of Directly Compressible Orally Disintegrating Tablets of Cannabidiol…
This study demonstrated the implementation of a liquisolid technique to formulate directly compressible orally disintegrating tablets (ODTs). Cannabidiol (CBD), a hydrophobic cannabinoid, was prepared as a liquisolid powder using microcrystalline cellulose–colloidal silicon dioxide as a…
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JRS PHARMA Announces New Clean Label Excipient LUBRITAB® RBW
Patterson, NY USA, November 2022 - JRS PHARMA proudly introduces its newest all-natural excipient: LUBRITAB® RBW. Developed as a lubricant for tablet and capsule formulations, LUBRITAB® RBW is suitable for use in direct compression and continuous manufacturing, as well as in wet or dry granulation…
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High-Shear Wet Granulation of SMEDDS Based on Mesoporous Carriers for Improved Carvedilol Solubility
Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve the solubility of poorly water-soluble drugs. They are known for high liquid load capacity and the ability to maintain characteristics of dry, free-flowing…
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