Magnesium stearate, also known as magnesium octadecanoate, is a common additive used in the pharmaceutical industry. It is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
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Magnesium Stearate
Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of enteric semipermeable capsule shell and the core prescription…
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A Novel Composite Dosage Form for Buccal Drug Administration
The potential of alternative routes of application compared to the traditional oral route is constantly growing. Especially in transmucosal applications for the oral cavity, easy accessibility is an attractive feature with many new opportunities.
The combination of a minitablet and a buccal…
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Reducing Friability of Tablets for Film Coating by Using Ceolus KG-1000
In the tablet film coating process, especially when it comes to large tablets especially with the size more than ø9mm, friability can be an issue at the early stage of the process. The purpose of the experiment was to confirm if Ceolus™ KG-1000, Asahi Kasei’s Microcrystalline Cellulose (“MCC”) with…
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Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably not only the high level of process understanding and…
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A study on the influence of the dissolution test factors on in vitro release of ibuprofen from…
Objectives
The aim of this study was to investigate the influence of in vitro release test parameters on the release of ibuprofen from sustained release inert matrix tablets.
Materials and methods
Ibuprofen sustained release inert matrix tablets were manufactured at a laboratory scale using…
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Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of…
Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared from different types of starter pellets (inert cores)…
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Robustness Optimization of an Existing Tablet Coating Process Applying Retrospective Knowledge…
The objective of these studies is to verify and validate the improvement in the inter-tablet coating uniformity for an industrially commercialized coated tablet, without involving changes in the approved registration dossier. Using the CPP (critical process parameters) determined from previous…
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The EsoCap-system – An innovative platform to drug targeting in the esophagus
For the therapy of esophageal diseases such as eosinophilic esophagitis, there are no possibilities of local targeted therapy. This publication describes a novel, innovative drug delivery concept, that enables a targeted, long-lasting administration of drug substances to the esophageal mucosa. In…
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Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic…
The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40…
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Characterization and modeling of the viscoelasticity of pharmaceutical tablets
Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity,…
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