Magnesium stearate, also known as magnesium octadecanoate, is a common additive used in the pharmaceutical industry. It is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
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Magnesium Stearate
Extemporaneous preparation of paediatric oral formulations with sildenafil citrate
The paediatric population is composed of several very diferent subgroups, each with its own specifc characteristics. For this reason, children cannot be considered “small adults”. The development of formulations suitable for children is a complex process, as it must consider the physiological…
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Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium
Mini-tablets (MTs) with losartan potassium were developed to treat the rare disease Epidermolysis Bullosa. The focus was placed on transfer and scale-up of a direct compressible formulation from the compaction simulator STYL’One Evo (CS) to the rotary tablet press Korsch XM 12 (RP). Transfer of…
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Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the…
Various approaches have been developed to enhance the solubility or dissolution rate for the delivery of poorly water-soluble molecules. In this work, guided by an in silico solubility sensitivity analysis for oral absorption, a comparative assessment of the biopharmaceutical performance of a…
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The influence of directly compressible fillers/diluents on selected compact properties and drug…
Introduction
Direct compression represents a favorable tablet manufacturing method. However, obtaining satisfactory mechanical properties of the compacts and drug dissolution remains a challenge in formulation development, particularly in the case of challenging model drugs. Rivaroxaban is…
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The Preparation and Evaluation of Cyanocobalamin Mucoadhesive Sublingual Tablets
Cobalamin (vitamin B12), an essential vitamin with low oral bioavailability, plays a vital role in cellular functions. This research aimed to enhance the absorption of vitamin B12 using sublingual mucoadhesive tablets by increasing the residence time of the drug at the administration site. This…
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Formulation and In Vitro Evaluation of Taste- Masked Prednisolone Orodispersible Tablets
Abstract
Background: Prednisolone is a corticosteroid with a very bitter taste acts as anti- anti-inflammatory and immune suppressant drug and it is used at any age.
Objective: To improve patient compliance by masking the bitter taste of the drug to be delivered as an orodispersible tablet.…
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Biocompatible hydroxy double salt tablet formulations
Generally, commercial extended release tablets are core-based, which can cause problems for certain patients if they split them prior to ingestion. There is a need to develop non-core-based extended release tablets. We have previously reported the synthesis of two new biocompatible hydroxy double…
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Study of Microcrystalline Cellulose as a Substitute of Magnesium Stearate Towards Functionality of…
Abstract
In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it decreases hardness of tablet in some formulations.…
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Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical…
Abstract
Introduction
Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming components by lubricant particles, resulting in decreased…
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Leveraging a multivariate approach towards enhanced development of direct compression extended…
Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to develop extended release formulations is direct compression, which offers…
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