Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Analysis of the impact of material properties on tabletability by principal component analysis and…
Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material library including 119 material descriptors and tablet tensile…
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A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction…
Abstract
This research investigates the modeling of the pharmaceutical roller compaction process, focusing on the application of the Johanson model and the impact of varying roll speeds from 1 to 15 RPM on predictive accuracy of ribbon solid fraction. The classical Johanson’s model was integrated…
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Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC – What is Coming Next?
Abstract
Oral peptide delivery is trending again. Among the possible reasons are the recent approvals of two oral peptide formulations, which represent a huge stride in the field. For the first time, gastrointestinal (GI) permeation enhancers (PEs) are leveraged to overcome the main limitation…
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Transformation of ABT-199 Nanocrystal Suspensions into a Redispersible Drug Product – Impact…
The present study compared vacuum drum drying (VDD) and conventional spray drying (SD) for solidifying crystalline ABT-199 nanosuspensions into redispersible oral drug products. The aim was to optimize formulation compositions and process conditions to maintain nanoparticle size after tablet…
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Lessons to learn for 3D printing of drug products by semisolid extrusion (SSE)
Abstract
Semisolid extrusion (SSE) 3DP technology is emerging due to its simplicity and potential for on-site manufacturing of personalized drug products with tailored functionality (dose, release profile), as well as recognizability (size, shape, color). However, even a minor change in the…
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Designing starch-based fenofibrate formulations using the melting method
Fenofibrate (FNF) is used to treat hyperlipidemia. However, FNF is a poorly water-soluble drug, and the dosage of commercial products is relatively high at 160 mg in a Lipidil® tablet. Therefore, this study aimed to develop an FNF-solid dispersion (SD) that solubilizes and stabilizes FNF. The…
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Design of easily swallowable xerogel pill with enough physical strength through hardening-process…
The xerogel pill has been developed as a novel dosage form with dose-adjusting and swallow-assisting functions by using drop freeze-drying (DFD) technique. It was double-structured small sphere composed of an inner drug core and an outer dried-gel layer, however, had problem of insufficient physical…
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Specific surface area of mannitol rather than particle size dominant the dissolution rate of poorly…
The dissolution behavior of tablets, particularly those containing poorly water-soluble drugs, is a critical factor in determining their absorption and therapeutic efficacy. Traditionally, the particle size of excipients has been considered a key property affecting tablet dissolution. However,…
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Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled…
One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a hydrophilic matrix forming polymer such as hydroxypropyl methylcellulose (HPMC), which is tableted via direct compression. However, HPMC may pose problems in direct…
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Trends in amorphous solid dispersion drug products approved by the U.S. Food and Drug Administration…
Abstract
Forty-eight (48) drug products (DPs) containing amorphous solid dispersions (ASDs) have been approved by the U.S. Food and Drug Administration in the 12-year period between 2012 and 2023. These DPs comprise 36 unique amorphous drugs. Ten (10) therapeutic categories are represented, with…
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