Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms…
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Fixed-dose dry powder for inhalation of nintedanib, pirfenidone and mycophenolic acid by thin-film…
Nintedanib and pirfenidone have been approved to treat idiopathic pulmonary fibrosis (IPF) by delaying progression of the disease. Recently, mycophenolic acid has also been used as an additive treatment for IPF. This study aims to produce and evaluate fixed-dose combinations (i.e., two-drug and…
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A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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3D Printing Technology: A New Approach for the Fabrication of Personalized and Customized…
3DP is a computer-aided design with the interesting innovation of prototyping layer-by-layer, creating 3D articles as digital blueprints to accomplish unequaled gracefulness, time protection, and extraordinary assembling ability of pharmaceutical dosage forms. 3D printing technology offers a novel…
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Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for…
HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from…
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A prediction system: regulating effect of small-molecule additives on properties of amorphous solid…
Abstract
Amorphous solid dispersions (ASDs) with solubility advantage are suffering from the recrystallization risk and subsequent reduced dissolution triggered by high hygroscopicity of hydrophilic polymers and the supersaturation of ASD solutions. To address these issues, in this study,…
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How to ensure a successful tablet coating formulation development by using polyvinyl alcohol and…
Purpose
Recent ban of titanium dioxide (TiO2; E171) for the use in food and nutritional supplements (European Commission). The regulation includes a commitment to review the necessity of titanium dioxide as a white colorant in medicinal products1.
It is challenging to find a suitable…
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The impact of material chemistry and morphology on attrition behavior of excipients during high…
Particle breakage by attrition is unavoidable in some unit operations and can lead to uncontrolled behavior of materials during processing. The aim of this study is to clarify the impact of material properties on attrition behavior. For the first time, an integral study with varying morphologies and…
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Solving capping challenges using mannitol as an excipient model
Pharma Excipients & Roquette present the new webinar:
Solving capping challenges using mannitol as an excipient model
Date & Time:
Jun 27, 2023 03:00 PM CET, 9:00 AM EST
Register here
Description:
During drug development formulators are focusing on Improving patient…
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A case study on distributed manufacturing of 3D printed medicines
Pharmaceutical 3D printing (3DP) is one of the emerging enabling technologies of personalised medicines as it affords the ability to fabricate highly versatile dosage forms. In the past 2 years, national medicines regulatory authorities have held consultations with external stakeholders to adapt…
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