Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
Browsing Category
Mannitol
PEARLITOL® CR-H by Roquette
SEE PEARLITOL® CR-H
Roquette´s new, industry-first mannitol and hydroxypropyl methylcellulose (HPMC) blend, designed for controlled release drug formulation. Leave behind wet granulation, lengthy drying times and limited flowability and unlock the potential of direct compression to create…
Read More...
Read More...
Effect of co-processed excipient type on properties of orodispersible tablets containing captopril,…
An important feature of orodispersible tablets (ODTs) is the convenient administration of the drugs, in some cases, faster onset of action, stability maintenance, and dose precision. This work focused on the preparation of ODTs containing mannitol-based co-processed excipients Prosolv® ODT G2,…
Read More...
Read More...
Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations…
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in…
Read More...
Read More...
Predicting pharmaceutical powder flow from microscopy images using deep learning
The powder flowability of active pharmaceutical ingredients and excipients is a key parameter in the manufacturing of solid dosage forms used to inform the choice of tabletting methods. Direct compression is the favoured tabletting method; however, it is only suitable for materials that do not show…
Read More...
Read More...
Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct…
Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study. Famotidine/mannitol (FA/MA) binary solution was spray dried…
Read More...
Read More...
Polyols Permeability on Caco-2 Cells and Their Effects on Transport of Low-Permeability Drugs
Some pharmaceutical excipients are able to modify intestinal permeability, thus influencing drug absorption and bioavailability. The effect of four polyols (mannitol, maltitol, sorbitol and xylitol) on the permeability of seven active pharmaceutical ingredients (API), representing different BCS…
Read More...
Read More...
Advanced image analytics to study powder mixing in a novel laboratory scale agitated filter dryer
Powder mixing unit operations are essential to the manufacturing of pharmaceutical drug substance and drug products. To model powder mixing, computational approaches have been used to evaluate mixing indices for different types of mixers, while also necessitating experimental methods for tracking of…
Read More...
Read More...
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability:…
Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable…
Read More...
Read More...
Optimising nasal powder drug delivery – Characterisation of the effect of excipients on drug…
The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional excipients are strategies to improve drug absorption. As nasal…
Read More...
Read More...
Upscaling of external lubrication from a compaction simulator to a rotary tablet press
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction…
Read More...
Read More...