Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Applicability of Expert System for Drug Development as a tool for co-processed excipients…
Expert System for Drug Development, i.e. SeDeM Expert System (Span. Sistema Experto para DEsarrollo de Medicamentos) represents a method intended for evaluation of powder properties affecting processability, particularly compression behavior (Pérez et al., 2006). Additionally, it is recognized as…
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Formulation and Characterisation of Carbamazepine Orodispersible 3D-Printed Mini-Tablets for…
Abstract
One of the main challenges to paediatric drug administration is swallowing difficulties, hindering the acceptability of the medicine and hence clinical outcomes. This study aims at developing a child-appropriate dosage form, the orodispersible mini-tablet (ODMT), using the model drug…
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Development of spray-dried N-acetylcysteine dry powder for inhalation
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its possible role in reducing the affinity of the spike protein receptor binding domain to angiotensin-converting…
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Temperature Cycling-Induced Formation of Crystalline Coatings
The surface of particles is the hotspot of interaction with their environment and is therefore a major target for particle engineering. Particles with tailored coatings are greatly desired for a range of different applications. Amorphous coatings applied via film coating or microencapsulation have…
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Formulation-dependent stability mechanisms affecting dissolution performance of directly compressed…
During drug product development, stability studies are used to ensure that the safety and efficacy of a product are not affected during storage. Any change in the dissolution performance of a product must be investigated, as this may indicate a change in the bioavailability. In this study, three…
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Relative Humidity Cycling: Implications on the Stability of Moisture-Sensitive Drugs in Solid…
The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment’s relative humidity (RH) and the products’ prior exposure to moisture. This study was designed to understand drug stability in relation to the moisture interaction of the excipients, moisture…
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A functional study of tubing material for the spray drying of mRNA-lipoplexes
Kiel University, Germany, and Meggle GmbH & Co. KG present "A functional study of tubing material for the spray drying of mRNA-lipoplexes":
INTRODUCTION
The overall aim of this project is the development of an inhalable dry powder platform for mRNA vaccines.
As many viral infections…
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Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young…
It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases…
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Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets
Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property…
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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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