Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Influence of the Binder Jetting Process Parameters and Binder Liquid Composition on the Relevant…
Binder jetting has the potential to revolutionize the way we produce medicine. However, tablets produced by binder jetting technology can be quite fragile and hard to handle. In this study, the printing process and ink composition were examined to optimize the mechanical properties of tablets. A…
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Formulation of sustain release matrix tablet of anti-anginal drug based on Eudragit L 100-55:…
This study aims to design and evaluate oral sustained release matrix tablets of BCS class 2 anti-anginal drug using Eudragit L 100-55 as the retardant polymer and mannitol as a channeling agent for the delivery of anti-anginal drug as twice-daily dose. The tablets were made using the traditional wet…
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Impact of alternative lubricants on process and tablet quality for direct compression
Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The…
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From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form
Praziquantel (PZQ) is an antihelmintic drug used worldwide against Schistosomiasis, despite its low solubility, bioavailability and the disgusting taste. This research represents a preliminary screening of 6 selected sweeteners in terms of their aptitude to be ground with PZQ, towards the…
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Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization,…
Esomeprazole magnesium (EMP) is a proton pump inhibitor (PPI) that reduces acid secretion. EMP has a short plasma half-life (approximately 1.3 h); hence, nocturnal acid breakthrough (NAB) frequently occurs, disturbing the patient’s nighttime comfort and sleep. We aimed to develop a novel…
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Roquette Expands PEARLITOL® SD Mannitol Range for Highly Sensitive Active Pharmaceutical…
Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical excipients, today announces the addition of a new grade to its PEARLITOL® SD mannitol range for direct compression – PEARLITOL® 150 SD. Developed specifically for active pharmaceutical ingredients (APIs)…
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Near Elimination of In Vitro Predicted Extrathoracic Aerosol Deposition in Children Using a…
Purpose
This study evaluated the in vitro aerosol performance of a dry powder antibiotic product that combined a highly dispersible tobramycin powder with a previously optimized pediatric air-jet dry powder inhaler (DPI) across a subject age range of 2–10 years.
Methods
An excipient enhanced…
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Spray freeze drying for protein encapsulation: Impact of the formulation to morphology and stability
Proteins, the building blocks of life, are increasingly being used as therapeutics for treating several diseases. Yet, there are challenges in the delivery of highly labile materials like proteins, which is often circumvented with the help of encapsulation for targeted delivery and enhanced…
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Compounding Tailored Veterinary Chewable Tablets Close to the Point-of-Care by Means of 3D Printing
Certain patient populations receive insufficient medicinal treatment due to a lack of commercially available products. The number of approved veterinary products is limited, making animals a patient population with suboptimal medicinal treatments available. To answer to this unmet need, compounding…
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Formulation development of loratadine immediate-release tablets using hot-melt extrusion and 3D…
The main goal of this study was to develop immediate release Fused Deposition Modeling (FDM) 3D printed loratadine tablets using hot-melt extrusion (HME) filaments. Loratadine was used as a model drug with 10% (w/w) drug loading. Ten different formulations were prepared using Crospovidone and…
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