Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Advantages of Mannitol in Pharmaceutical Granulation Processes – A Comparison of Different…
Granulation is employed during production of oral dosage forms to convert small particles of powder ingredients and the active pharmaceutical ingredient (API) into large, free-flowing, dust-free, compressible granules, ensuring uniform distribution of ingredients throughout the resulting mixture.…
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Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical…
Biopharmaceuticals are formulated using a variety of excipients to maintain their storage stability. However, some excipients are prone to degradation during repeated use and/or improper storage, and the impurities generated by their degradation are easily overlooked by end users and are usually not…
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Role of arginine salts in preventing freezing-induced increase in subvisible particles in protein…
While arginine hydrochloride (ArgHCl) has emerged as a potential stabilizer of protein drugs in liquid formulations, the purpose of this manuscript was to evaluate its stabilization potential in frozen solutions. The phase behavior of frozen ArgHCl solutions was investigated by differential scanning…
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Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of…
Background: Cystic fibrosis (CF) is a genetic disorder, in which defective clearance of airway secretions leads to progressive lung function loss. Inhaled mannitol is used to increase sputum and mucociliary clearance. There are little data from real-world studies on the effectiveness of mannitol in…
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HiSORAD™ – Solving content uniformity issues in ODT prepared by direct compression
Introduction
Direct compression is the simplest tableting method, contributing to both energy savings and cost advantages. However, maintaining content uniformity of active pharmaceutical ingredient (API) in tablets prepared by direct compression can be challenging, as powders with different…
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Bilayer Buccal Tablets of Furosemide: Design and Evaluation
Aim: In the present study, mucoadhesive bilayer buccal tablets of furosemide were fabricated with the objective of avoiding first-pass metabolism and enhancing the bioavailability along with reducing the dosing frequency.
Methodology: Direct compression method was used to prepare bilayer buccal…
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Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung…
It has recently emerged that drugs such as the mTOR inhibitor rapamycin (Rapa) may play a key role in the treatment of airway inflammation associated with lung diseases, such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis. Nevertheless, Rapa clinical application is still…
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Understanding Heat Transfer During the Secondary Drying Stage of Freeze Drying: Current Practice and…
Currently, there is a lack of robust models for secondary drying with comparable accuracy and flexibility as primary drying models. In order to better understand heat transfer during secondary drying, sucrose and mannitol solutions were freeze-dried in vials in a lab-scale lyophilizer under various…
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Lyophilized tablets of felodipine-loaded polymeric nanocapsules to enhance aqueous solubility:…
The aim of this study was to enhance the physicochemical properties of felodipine through the formulation of lyophilized polymeric nanocapsule tablets. Felodipine was loaded into polymeric nanocapsules composed of Labrafac™ PG (an oil solubilizer) and Eudragit® EPO (cationic coating polymer) using…
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Pharmatrans specific functional starter cores for improved bioavailability and dissolution
Pharmatrans Sanaq specialized range of pharmaceutical excipients and novel drug vehicles includes pellets to aid design of various types of solid dosage forms.
The range has been extended from standard types of microcrystalline cellulose, such as neutral starter cores CELLETS®, purely made of…
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