Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Effects of drying method and excipient on the structure and physical stability of protein solids:…
This study aims to determine the impacts of drying method and excipient on changes in protein structure and physical stability of model protein solids. Protein solids containing one of two model proteins (lysozyme or myoglobin) were produced with or without excipients (sucrose or mannitol) using…
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Current Status in the Utilization of Biobased Polymers for 3D Printing Process
Three-dimensional (3D) printing is a revolutionary additive manufacturing technique that allows rapid prototyping of objects with intricate architectures. This Review covers the recent state-of-the-art of biopolymers (protein and carbohydrate-based materials) application in pharmaceutical,…
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Orally Disintegrating Tablets? HiSORAD – Directly Compressible Excipient for ODTs –…
HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD enables to produce ODTs by direct compression with three advantages: Practical flowability, excellent…
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A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
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A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was developed to determine the granule density using the…
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Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30 mL/h feeding rate, which is about 30x higher than the…
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A fully customized single-use packaging solution
Now available for Roquette’s full biopharma portfolio including:
KLEPTOSE® HP/HPB BioPharma 2-hydroxypropyl-betacyclodextrin
NEOSORB® BioPharma sorbitol
PEARLITOL® BioPharma mannitol
LYCADEX® BioPharma dextrose monohydrate
Dextrose…
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Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting…
Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clinical and biopharmaceutical benefits. But technological aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and tableting pressure for industrially relevant…
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Advanced design and development of nanoparticle/microparticle dual-drug combination lactose…
Lactose is the only FDA-approved carrier for dry powder inhaler (DPI) formulations in the US. Lactose carrier-based DPI products are contraindicated in patients with a known lactose allergy. Hence, inhaler formulations without lactose will benefit lactose allergic asthmatics.
Objectives: to…
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Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan…
In clinical practice, a thickening solution is frequently used to allow easy swallowing of tablets by patients suffering from dysphagia. This study investigated the effect of the thickening solution on tablet disintegration. Model tablets containing different disintegrants were prepared and their…
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