Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
Browsing Category
Mannitol
Impact of Magnesium Stearate Content: Modeling of Drug Degradation Using a Modified Arrhenius…
To accelerate drug development, the pharmaceutical industry is working to shorten and improve studies on stability. The Accelerated Stability Assessment Program (ASAP) incorporating the humidity-corrected Arrhenius equation as an accelerated methodology has been proposed for both drug substances…
Read More...
Read More...
Meggle Reta M® – The Interview
MEGGLE released the new excipient Reta M® at October 13. Pharma Excipients used the chance to do an interview with the responsible product manager, Dr. Christian Nowak, to learn more about Reta M®. It is the first hypromellose/mannitol-based, co-processed excipient specifically designed for direct…
Read More...
Read More...
Mannitol in wet granulation
Wet granulation is commonly used in the pharmaceutical industry to manufacture oral solid dosage forms. Owing to many favorable attributes, mannitol is finding increasing use as a pharmaceutical binder in these formulations. Standard crystallized mannitol in β-polymorphic form, while excellent for…
Read More...
Read More...
Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal…
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not…
Read More...
Read More...
Development of piroxicam mini-tablets enabled by spherical cocrystallization
We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The manufacturing of mini-tablets using a direct compression (DC) process…
Read More...
Read More...
Directly compressible excipient for orally disintegrating tablets
Orally disintegrating tablets (ODTs) are one of the most popular dosage forms for improving medication adherence. ODTs disintegrate in saliva in the oral cavity without requiring water. This allows patients with dysphagia, as well as geriatric and pediatric populations, to easily swallow the…
Read More...
Read More...
Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations
Co-processing specialist MEGGLE Excipients & Technology (MEGGLE) has developed Reta M®. The first hypromellose/mannitol-based, co-processed excipient specifically designed for direct compression (DC) and dry granulation of modified release formulations for the pharmaceutical and nutraceutical…
Read More...
Read More...
Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet…
This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were stored at 25 °C, 75% relative humidity for 1 week. Then,…
Read More...
Read More...
Twin-screw granulation and high-shear granulation: the influence of mannitol grade on granule and…
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of input grade has been shown to impact granule properties.…
Read More...
Read More...
Disintegration property of ODTs with co-processed excipients – Application note
Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs.
Orally disintegrating tablets (ODTs) have gotten attention as they improve medication adherence for patients who have issues in swallowing,…
Read More...
Read More...