Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules…
The particle size reduction of active pharmaceutical ingredients is an efficient method to overcome challenges associated with a poor aqueous solubility. With respect to stability and patient’s convenience, the corresponding nanosuspensions are often further processed to solid dosage forms.
In…
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A study on the impact of HPMC viscosity grade and proportion on the functional properties of…
The co-processing of multiple excipients is driven by the potential of diversifying the properties and functionality of excipients when they are combined. Bulk freeze-drying-milling is a novel secondary processing approach to develop co-processed excipients. It offers a significant advantage of…
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Non-intrusive high resolution in-vitro measurement of regional drug powder deposition
Optical Coherence Tomography (OCT) is a high-resolution and non-invasive cross-sectional imaging technique mainly used for medical imaging and industrial non-destructive testing. However, its feasibility in the quantification of pulmonary drug deposition has not been investigated.
In this study,…
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A Microfluidic Platform to design Multimodal PEG – crosslinked Hyaluronic Acid Nanoparticles…
The combination of different imaging modalities can allow obtaining simultaneously morphological and functional information providing a more accurate diagnosis. This advancement can be reached through the use of multimodal tracers, and nanotechnology-based solutions allow the simultaneous delivery…
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Inhalable Nano into Micro Dry Powders for Ivacaftor Delivery: The Role of Mannitol and Cysteamine as…
In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two…
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Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation has been used to remove water molecules from the suspension.…
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Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the powder. In this work, we studied the influence of the speed on…
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Pfanstiehl Inc, USA- Helping accelerate COVID19 research to develop Vaccine, Diagnosis and Cure
Pfanstiehl (IL, USA) is a global leader in developing High Pure/Low Endotoxin Viral Vector, Protein and Vaccine stabilizers ( eg. HPLE-Trehalose, Sucrose, Histidine, Arginine ,Mannitol, Sodium Succinate etc.) that are used in producing many human vaccines and diagnostics worldwide.
As the global…
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SPI Pharma expands line of mannitol products
Announced by SPI Pharma - The Company has added four mannitols to its Mannogem line, designed for optimala compressibility, binding, disintegration and particle size ranges. Read the full artile here: SPI-RELEASES-MANNITOLS-FOR-MORE-PATIENT-FRIENDLY-TABLETS
By Jenni Spinner 30-Mar-2020…
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Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes:…
The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes.
Specifically, the effect of mannitol (MAN), sorbitol…
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