Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug‐cyclodextrin complexes and then combined with the filler mannitol.
Two…
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Roller compaction
Roller compaction is the main technique employed in dry granulation.
Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the…
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Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly…
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Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility.
By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle…
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A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine
Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection‐spray drying method. The response surface method was used to optimize formulation to enhance the encapsulation efficiency (EE%) of nifedipine. The…
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Fast Dissolving Tablets – An Updated Review
Fast dissolving tablets (FDTs) is one of the most widely accepted and popular dosage form, especially for paediatric and geriatric patients. Conventional solid dosage forms like tablets and capsules are facing the problems like difficulty in swallowing (dysphasia), resulting in many incidences of…
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Globular protein stabilized nanoparticles for delivery of disulfiram: fabrication, characterization,…
Disulfiram (DSF), an FDA-approved anti-alcoholic drug, has recently shown that it possesses anti-cancer effects. However, DSF is hydrophobic in nature with less stability. Therefore, new approaches are required for the effective delivery of DSF to treat cancers. Herein, we prepared DSF loaded soy…
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Spray-dried liposomes: A study of the effect of carbohydrate carrier and concentrations on liposome…
Background and objective: Dry powder inhalation provide many promising features for
drug delivery to the pulmonary system, such as localization of drug within the lungs, drug
retention in the respiratory tract, and reduced systemic toxicities. This study aimed to
prepare dry powders of liposomes…
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Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and…
Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold.
The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of…
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Advanced Tablet Coating Development: Applying Optical Coherence Tomography (OCT) as a PAT Tool for…
Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control procedures also approaches of in-line process analytical…
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