Mannitol is a sugar alcohol commonly used in the pharmaceutical industry for various purposes. It is a white, crystalline powder with a sweet taste and is known for its ability to act as an osmotic diuretic. Mannitol finds applications in pharmaceuticals due to its unique properties, including solubility, stability, and low toxicity.
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Mannitol
Freeze-Drying of Encapsulated Bacteriophage T4 to Obtain Shelf-Stable Dry Preparations for Oral…
Therapeutic application of bacterial viruses (phage therapy) has in recent years been rediscovered by many scientists, as a method which may potentially replace conventional antibacterial strategies. However, one of the main problems related to phage application is the stability of bacterial…
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Correlating mechanical and rheological filament properties to processability and quality of 3D…
Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation…
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Case Study PEARLITOL® 200 GT Mannitol: A Tool to Formulate Mini Tablets as a Compliant and Flexible…
PURPOSE
Mini tablets are a multiple unit dosage form with a size of less than 3.0 mm in diameter with great flexibility to deliver appropriate doses to the pediatric age group. They can be given in different numbers, according to dosage requirements, with no special prerequisite of formulating age…
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Successful Formulation Window for the design of pharmaceutical tablets with required mechanical…
Abstract
Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based predictive models for binary and ternary formulations to establish an acceptable range of tablet compression parameters that satisfy…
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Development and characterization of a spray-dried inhalable ternary combination for the treatment of…
Cystic fibrosis (CF) is an inherited lung disease characterised by the accumulation of thick layers of dried mucus in the lungs which serve as a nidus for chronic infection. Pseudomonas aeruginosa is the predominant cause of chronic lung infection in cystic fibrosis. The dense mucus coupled with…
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Understanding the impact of mannitol on physical stability and aerosolization of spray-dried protein…
Abstract
Pulmonary delivery of protein-based therapeutics, including antibodies, is a promising option for treating respiratory diseases. Spray drying is a widely used method for producing dry powder formulations with mannitol being a commonly used excipient for these inhalation formulations. There…
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Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and moisture content. Process analytical technologies (PATs) are…
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Formulation and characterization of medicated chewing gum containing zingiberine for treatment of…
The objective of this work was to formulate zingiberine as medicated chewing gum for improving its bioavailability. The objective was achieved by isolating zingiberine form ginger oil and formulating chewing gum using zein as the gum base by melting method. The formulation of ZCGs was achieved using…
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Interaction of thermal and rheological parameters critical for the processability of polyvinyl…
Purpose
Hot melt extrusion (HME) is a pivotal pharmaceutical manufacturing process employed to enhance the bioavailability of poorly soluble active pharmaceutical ingredients (APIs) in oral dosage forms. Often the applicability of the process is limited by the melt viscosity. The upper limit is…
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3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the…
Established medicines are often not tailored to the needs of the pediatric population, causing difficulties with administration or dosing. Three-dimensional (3D) printing technology allows novel approaches for compounding of personalized medicine, as is exemplified in this study for the automated…
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