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Microneedle
Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity
Vaccination is an essential public health measure for infectious disease prevention. The exposure of the immune system to vaccine formulations with the appropriate kinetics is critical for inducing protective immunity. In this work, faceted microneedle arrays were designed and fabricated utilizing a…
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Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained…
Fungal infections affect millions of people globally and are often unreceptive to conventional topical or oral preparations because of low drug bioavailability at the infection site, lack of sustained therapeutic effect, and the development of drug resistance. Amphotericin B (AmB) is one of the most…
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Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer
Highlights
• Microneedles are promising devices used for painless transdermal drug delivery.
• Biological effects of therapeutic agents can be improved by tuning their release behavior.
• Microneedles can be employed for immunotherapy.
• Combinatory approaches with…
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Devices for drug delivery in the gastrointestinal tract: a review of systems physically interacting…
The delivery of macromolecules via the gastrointestinal (GI) tract remains a significant challenge. A variety of technologies using physical modes of drug delivery have been developed and investigated to overcome the epithelial cell layer of the GI tract for local and systemic delivery. These…
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Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept…
Although microneedle array patch (MAP) technology is reaching ever closer to regulatory approval, it remains imperative that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-filled reservoir was incorporated into a hydrogel-forming MAP system…
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Microneedle array with a pH-responsive polymer coating and its application in smart drug delivery…
For successful wound treatment, therapeutics must be delivered directly to the wound. Various issues restrict the delivery of antibiotics to wounds, including the barrier mannered by necrotic tissue and biofilms, which create an extracellular polymeric layer that impedes the efficient…
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Polymeric microneedles for transdermal delivery of nanoparticles: Frontiers of formulation,…
With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes. Among the various types of MNs, polymeric microneedles (PMNs)…
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Development of a thermostable oxytocin microneedle patch
Oxytocin is a nonapeptide hormone used in labor to initiate uterine contractions and to prevent and treat postpartum hemorrhage. Oxytocin is currently administered by injection and requires refrigerated transport and storage, which limits access, especially during home birth in developing countries.…
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3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of…
A 3D printed assembly of hollow microneedles (HMNs) array, conjoined with a reservoir void, was designed and additively manufactured using stereolithography (SLA) technology utilizing a proprietary class-I resin. The HMNs array was utilized for transdermal delivery of high molecular weight …
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Diving into 3D (bio)printing: A revolutionary tool to customize the production of drug and…
The incorporation of 3D printing technologies in the pharmaceutical industry can revolutionize its R&D, by providing a simple and rapid method to produce tailored one-off batches, each with customized dosages, different compounds, shapes, sizes, and adjusted release rates. Particularly, this…
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