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Microneedle
Microneedle-based biosensing
Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the skin, which contains a variety of metabolites that can serve as biomarkers. The collection of interstitial fluid…
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Microneedles for advanced ocular drug delivery
In the field of ocular drug delivery, topical delivery remains the most common treatment option for managing anterior segment diseases, while intraocular injections are the current gold standard treatment option for treating posterior segment diseases. Nonetheless, topical eye drops are associated…
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Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive…
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in…
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Micro array patch assisted transdermal delivery of high dose, ibuprofen sodium using…
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly (vinylcaprolactam) thermoresponsive gels. Their phase transition property…
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Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient…
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Drug delivery systems for thyroid disease treatment: A mini review on current therapies and…
Thyroid hormones play an important role in many metabolic processes in the human body. However, these processes can often be disrupted by an over or underactivity of the thyroid gland which, if undiagnosed or untreated, can result in serious illness. Currently, therapeutic management of an…
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Long-acting microneedle formulations
The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active…
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Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the…
Malaria is a global parasitic infection that leads to substantial illness and death. The most commonly-used drugs for treatment of malaria vivax are primaquine and chloroquine, but they have limitations, such as poor adherence due to frequent oral administration and gastrointestinal side effects. To…
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Tip loaded cyclodextrin-carvedilol complexes microarray patches
Carvedilol, a β-blocker prescribed for chronic heart failure, suffers from poor bioavailability and rapid first pass metabolism when administered orally. Herein, we present the development of tip microarray patches (MAPs) composed of ternary cyclodextrin (CD) complexes of carvedilol for transdermal…
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Technical evaluation of precisely manufacturing customized microneedle array patches via inkjet drug…
Dissolvable microneedle array patches offer the possibility to deliver active pharmaceutical ingredients bypassing the gastrointestinal tract by piercing the stratum corneum. Usually, microneedles are produced by micromolding but this often results in a waste of active pharmaceutical ingredient. In…
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