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Mucoadhesion
Types and evaluation of in vitro penetration models for buccal mucosal delivery
Oral buccal mucosal delivery has the advantage of avoiding gastrointestinal drug degradation, reducing hepatic firstpass effects, and improving patient compliance. In recent years, it is becoming a drug delivery route that researchers have paid attention to. One of the major constraints to bringing…
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Role of Polymer Physicochemical Properties on in vitro Mucoadhesion
Polymers with mucoadhesive properties are universally used in the development of mucoadhesive drug delivery system. Their physicochemical properties as well as the mechanisms related to their adhesive actions draw great attention for the modification of mucoadhesive properties.
In this study,…
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Mucoadhesive in situ forming gel for oral mucositis pain control
The current first line therapy for oral mucositis pain control is unsatisfactory as it results in only a short duration of modest pain relief. Developing mucoadhesive in situ forming formulations to prolong pain relief is challenging due to their complex physicochemical properties and the unique…
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S-protected thiolated hydroxyethyl cellulose (HEC): novel mucoadhesive excipient with improved…
08. March 2016
The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified polymer. Thiolated HEC was S-protected via disulfide bond…
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Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
19. February 2016
Design and Evaluation of Buccal Patch Containing Combination of Hydrochlorothiazide and Lisinopril
Purpose: The objective of the present study was to formulate and evaluate buccal patches containing combination of lisinopril (LP) and hydrochlorothiazide (HCZ).…
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Tragacanth as an oral peptide and protein delivery carrier: characterization and mucoadhesion
08. February 2016
Biopolymers such as tragacanth, an anionic polysaccharide gum, can be alternative polymeric carrier for physiologically important peptides and proteins. Characterization of tragacanth is thus essential for providing a foundation for possible applications.…
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