Micro and nanoscale technologies in oral drug delivery
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro- and nanoscale technologies, with an unprecedented ability to create, control, and measure micro- or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery.
In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including the fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.
Read more on Micro and nanoscale technologies in oral drug delivery
Author links open overlay panelSamad Ahadian, Joel A.Finbloom, Mohammad Mofidfar, Sibel Emir Diltemiz, Fatemeh Nasrollahi, Elham Davoodi, Vahid Hosseini, Ioanna Mylonaki, Sivakoti Sangabathuni, Hossein Montazerian, Kirsten Fetah, Rohollah Nasiri, Mehmet Remzi Dokmeci, Molly M.Stevens, Tejal A.Desai, Ali Khademhosseini
Advanced Drug Delivery Reviews
Available online 22 July 2020, In Press, Journal Pre-proof
https://doi.org/10.1016/j.addr.2020.07.012