Nanotechnology for excipients (or “nanotech”) is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The National Nanotechnology Initiative defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.
Pharma Excipients
Nanotechnology
A new perspective for psoriasis: Dithranol nanosponge loaded hydrogels
We developed dithranol nanosponge integrated Carbopol hydrogel (DTHNS-HG) as a novel perspective for psoriasis management. Dithranol was chosen as antipsoriatic moiety for this system. In this study, our objective was to fabricate and evaluate DTHNS-HG for in vivo anti-psoriatic activity using mouse…
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Plant Bioactive Ingredients in Delivery Systems and Nanocarriers for the Treatment of Leishmaniasis:…
Background: This study was designed considering the challenges of leishmaniasis treatment and the benefits of carriers of drug delivery systems to review plant bioactive ingredients in delivery systems and nanocarriers for the treatment of leishmaniasis.
Methods: The methodology of this review…
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A Current Overview of Cyclodextrin-Based Nanocarriers for Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals,…
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Encapsulation of cannabidiol in oil-in-water nanoemulsions and nanoemulsion-filled hydrogels: a…
Abstract
Hypothesis
Lipophilic cannabidiol can be solubilized in oil-in water nanoemulsions, which can then be impregnated into chitosan hydrogels forming another colloidal system that will facilitate cannabidioil's release. The delivery from both systems was compared, alongside structural and…
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Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for…
Oral squamous cell carcinoma (OSCC) is the most common epithelial tumor of the oral cavity. Gingival tumors, a unique type of OSCC, account for 10% of these malignant tumors. The antineoplastic properties of statins, including pitavastatin (PV), and the essential oil of the Pinus densiflora leaf (Pd…
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Nanochannel delivery system for CBD: Sustained low level plasma levels without liver toxicity
Cannabidiol (CBD) is a plant-derived cannabinoid found in marijuana and hemp that has been intensely investigated for its putative anti-inflammatory, anxiolytic and/or analgesic effects. Since all these conditions require long-term treatment, sustained release formulations are being investigated.…
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Synthesize of the chitosan-TPP coated betanin-quaternary ammonium-functionalized mesoporous silica…
Advanced glycation end products (AGEs) are harmful by-products of thermal-processing of food. Betanin is an antioxidant with the potential to inhibit AGEs formation. In this work, we encapsulated betanin in chitosan-sodium tripolyphosphate coated quaternary ammonium-functionalized mesoporous silica…
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Differential Surface Engineering Generates Core–Shell Porous Silicon Nanoparticles for Controlled…
An approach to differentially modify the internal surface of porous silicon nanoparticles (pSiNPs) with hydrophobic dodecene and the external surface with antifouling poly-N-(2-hydroxypropyl) acrylamide (polyHPAm) as well as a cell-targeting peptide was developed. Specifically, to generate these…
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Exploring the effect of intramuscularly injected polymer/lipid hybrid nanoparticles loaded with…
The current study intended to develop a new treatment of schizophrenia having a sustained release activity. Quetiapine fumarate (QF)-loaded polymer/lipid hybrid nanoparticulate systems of polycaprolactone (PCL) and Geleol™ were fabricated using polyvinyl alcohol (3% w/v). The proposed hybrid systems…
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Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and…
Abstract
Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent.…
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