Nanotechnology for excipients (or “nanotech”) is the use of matter on an atomic, molecular, and supramolecular scale for industrial purposes. The National Nanotechnology Initiative defined nanotechnology as the manipulation of matter with at least one dimension sized from 1 to 100 nanometers.
Pharma Excipients
Nanotechnology
Investigation of wound healing efficiency of multifunctional eudragit/soy protein isolate…
One significant aspect of the current therapeutic agents employed in wound healing involves the engineering of nano polymeric scaffolds to mimic the properties of extracellular matrix (ECM). The present work aimed to prepare and evaluate Eudragit® L100 (EU) nanofibers in combination with soy protein…
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Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous…
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards poorly soluble drugs and promote/sustain drug…
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Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica…
To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The dry coating performed with different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and a…
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Mechanisms and Pharmaceutical Application of Solid Lipid Nanoparticles as Efficient Drug Delivery…
Abstract
A solid lipid nanoparticle provides the opportunity of developing new therapies due to their unique size-dependent characteristics. They are a small particle that ranges between 1-100 nm in size. Lipid nanoparticles have risen in popularity in this context due to their widespread…
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Processing of Lipid Nanodispersions into Solid Powders by Spray Drying
Spray drying is a promising technology for drying lipid nanodispersions. These formulations can serve as carrier systems for poorly water-soluble active pharmaceutical ingredients (APIs) that are loaded into the lipid matrix to improve their bioavailability. Once the API-loaded nanocarriers have…
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TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems
Liposomes are sphere-shaped vesicles that can capture therapeutics either in the outer phospholipid bilayer or inner aqueous core. Liposomes, especially when surface-modified with functional materials, have been used to achieve many benefits in drug delivery, including improving drug solubility,…
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Development and characterization of amphotericin B nanoemulsion-loaded mucoadhesive gel for…
Despite being recognized as the “gold standard” for treating azole-resistant vulvovaginal candidiasis, amphotericin B (AmB), an amphoteric molecule, has not been widely used due to serious issues with solubility and permeability. In light of the aforementioned, the objective of the present study was…
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Redox responsive poly(allylamine)/eudragit S-100 nanoparticles for dual drug delivery in colorectal…
Herein, we report redox responsive, colon cancer targeting poly(allylamine) (PA)/eudragit S-100 (EU) nanoparticles (PAEU NPs) (≈59 nm). These disulfide crosslinked PAEU NPs are developed via air oxidation of thiolated PA and thiolated EU, eliminating the need of any external crosslinking agent for…
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Sustained and targeted delivery of hydrophilic drug compounds: A review of existing and novel…
The sustained and/or targeted delivery of hydrophilic drugs is an important field within drug delivery, presenting unique challenges when compared to that of hydrophobic drugs. Yet relatively few comprehensive reviews specific to hydrophilic drug delivery have been published recently. In this…
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Formulation Development and Evaluation of Herbal Nanoparticles containing Ointment of Leaves extract…
In our previous work we have reported wound healing activity of leaves extract of Rhynchosia rothii in which we got excellent activity. Therefore in present study, the development of Rhynchosia rothii loaded Lycoat RS 720-BSA conjugated polymeric nanoparticles and subsequent ointment formulation has…
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