A study on the plasticization of sustained release coatings for their ability to withstand the damaging effects of compaction on coated pellets
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Pharmaceutical solid dosage forms are commonly coated to modify the release of drugs. Due to the disadvantages of coated single-unit dosage forms, such as occurrences of dose dumping and local irritation, coated multi-particulates are preferred. Coated multi-particulates can eventually be filled into capsules or compressed into tablets. The latter is more desirable as unit production costs of tablets are considerably lower and machinery more easily available.